ORIGINAL ARTICLE
Effect of the mixed herbal medicines extracts on menopausal symptoms: A randomized clinical trial study
 
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1
I. M. Sechenov First Moscow State Medical University, Moscow, Russia
 
2
Central Clinical Hospital of Civil Aviation, Moscow, Russia
 
3
Sanatoriun “Laba”, Labinsk, Russia
 
 
Online publication date: 2019-05-16
 
 
Publication date: 2019-05-16
 
 
Electron J Gen Med 2019;16(3):em137
 
KEYWORDS
ABSTRACT
Background:
Menopause cause many symptoms, which may impair quality of life the women. The study aims to determine the effectiveness of mixed herbal medicinal extracts on menopausal symptoms.

Method:
A randomized, triple-blind, placebo-controlled clinical trial was conducted on 120 peri-menopausal women for 12 weeks. All participants took herbal extracts drops orally daily. They were randomly allocated into four groups: placebo (C), A (250 mg chamomile, 30 mg fennel, 15 mg saffron), B (1000 mg chamomile, 120 mg fennel, 60 mg saffron), and D (500 mg chamomile, 60 mg fennel, 30 mg saffron).They completed a demographic and MRS questionnaire at week 0, 6.12.

Result:
108 participants successfully completed the assessment. No significant differences in demographic variables were seen between the four groups. The median MRS score was significantly reduced in group B from 27.5±3 to 7.5±5. In group D, it was significantly reduced from 29±12 to 22±9.25The effect size in this study was 0.92.

Conclusion:
Study showed significant improvement in menopausal symptoms especially in group B.

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