ORIGINAL ARTICLE
Investigation Of Anti-Inflammatory Activity Of Bergamot Oil
 
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1
Yüzüncü Yıl University, Faculty of Veterinary Medicine, Department of Internal Medicine, Van, Turkey
 
2
Yüzüncü Yıl University, Medical Faculty, Department of Pharmacology, Van, Turkey
 
3
Yüzüncü Yıl University, Medical Faculty, Department of Physiology, Van, Turkey
 
 
Online publication date: 2007-10-15
 
 
Publication date: 2007-10-15
 
 
Corresponding author
Hanefi Özbek   

Yüzüncü Yıl Üniversitesi, Tıp Fakültesi Farmakoloji AD 65300 Van, Turkey Fax: 904322168352
 
 
Eur J Gen Med 2007;4(4):176-179
 
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ABSTRACT
Aim: Essential oil of Bergamot (BO) was investigated for anti-inflammatory activity using carrageenan-induced rat paw oedema test. Methods: For the anti-inflammatory activity measurement six different groups were established and BO was administered in three different doses: 0.025, 0.05 and 0.10 mL/kg. Indomethacin was used as a reference agent. Results: It was found that reduction in the inflammation was 95.70% with indomethacin, 27.56% with 0.025 mL/kg BO, 30.77% with 0.05 mL/kg BO and 63.39% with 0.10 mL/kg BO. Indomethacin showed the strongest anti-inflammatory activity among the drugs used. The strongest anti-inflammatory activity of BO was seen with 0.10 mL/kg dosage. Median effective dose (ED50) value of BO was found to be 0.079 mL/kg. Conclusion: The results showed that BO posseses promising anti-inflammatory effect.
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