Investigation Of Anti-Inflammatory Activity Of Bergamot Oil
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Yüzüncü Yıl University, Faculty of Veterinary Medicine, Department of Internal Medicine, Van, Turkey
Yüzüncü Yıl University, Medical Faculty, Department of Pharmacology, Van, Turkey
Yüzüncü Yıl University, Medical Faculty, Department of Physiology, Van, Turkey
Hanefi Özbek   

Yüzüncü Yıl Üniversitesi, Tıp Fakültesi Farmakoloji AD 65300 Van, Turkey Fax: 904322168352
Online publication date: 2007-10-15
Publication date: 2007-10-15
Eur J Gen Med 2007;4(4):176–179
Aim: Essential oil of Bergamot (BO) was investigated for anti-inflammatory activity using carrageenan-induced rat paw oedema test. Methods: For the anti-inflammatory activity measurement six different groups were established and BO was administered in three different doses: 0.025, 0.05 and 0.10 mL/kg. Indomethacin was used as a reference agent. Results: It was found that reduction in the inflammation was 95.70% with indomethacin, 27.56% with 0.025 mL/kg BO, 30.77% with 0.05 mL/kg BO and 63.39% with 0.10 mL/kg BO. Indomethacin showed the strongest anti-inflammatory activity among the drugs used. The strongest anti-inflammatory activity of BO was seen with 0.10 mL/kg dosage. Median effective dose (ED50) value of BO was found to be 0.079 mL/kg. Conclusion: The results showed that BO posseses promising anti-inflammatory effect.