CASE REPORT
Multiple endocrine neoplasia type 1 with brown tumors as first manifestation in a patient with pituitary adenoma: A case report
 
More details
Hide details
1
Hospital Nacional Arzobispo Loayza, Lima, PERU
 
2
Hospital Nacional Dos de Mayo, Lima, PERU
 
3
Universidad Científica del Sur, Lima, PERU
 
 
Publication date: 2022-05-08
 
 
Electron J Gen Med 2022;19(4):em384
 
KEYWORDS
ABSTRACT
Introduction:
Multiple endocrine neoplasia type 1 (MEN 1) is an infrequent autosomal dominant hereditary syndrome. Common manifestations are related to hypercalcemia, which is caused by primary hyperparathyroidism (PHPT). Brown tumors are infrequent as initial presentation of PHPT associated with MEN 1. It occurs in less than 2% of MEN 1 population.

Results:
A 36-year-old woman started the disease 25 years ago in an insidious and progressive manner. She presented a soft tumor in the left malar region that progressively increased in volume. We treated recurrent multiple brown tumors in a patient with PHPT and pituitary adenoma.

Conclusions:
The follow-up was demanding and multidisciplinary. The long-term prognosis is uncertain; therefore, close monitoring of the patient should be carried out through clinical, laboratory and imaging evaluation.

 
REFERENCES (9)
1.
Lu Y-Y, Zhu F, Jing D-D, et al. Multiple endocrine neoplasia type 1 with upper gastrointestinal hemorrhage and perforation: A case report and review. World J Gastroenterol. 2013;19(8):1322-6. https://doi.org/10.3748/wjg.v1... PMid:23482249 PMCid:PMC3587492.
 
2.
Ito T, Igarashi H, Uehara H, Berna MJ, Jensen RT. Causes of death and prognostic factors in multiple endocrine neoplasia type 1: A prospective study: Comparison of 106 MEN1/Zollinger-Ellison syndrome patients with 1613 literature MEN1 patients with or without pancreatic endocrine tumors. Medicine (Baltimore). 2013;92(3):135-81. https://doi.org/10.1097/MD.0b0... PMid:23645327 PMCid:PMC3727638.
 
3.
Al-Gahtany M, Cusimano M, Singer W, Bilbao J, Kovacs K, Marotta T. Brown tumors of the skull base. Case report and review of the literature. J Neurosurg. 2003;98(2):417-20. https://doi.org/10.3171/jns.20... PMid:12593633.
 
4.
Qaisi M, Loeb M, Montague L, Caloss R. Mandibular brown tumor of secondary hyperparathyroidism requiring extensive resection: A forgotten entity in the developed world? Case Rep Med. 2015;2015:567543. https://doi.org/10.1155/2015/5... PMid:26413096 PMCid:PMC4556817.
 
5.
Cicconetti A, Matteini C, Piro FR. Differential diagnosis in a case of brown tumor caused by primary hyperparathyroidism. Minerva Stomatol. 1999;48(11):553-8. PMid:10768015.
 
6.
Di Meo G, Sgaramella LI, Ferraro V, Prete FP, Gurrado A, Testini M. Parathyroid carcinoma in multiple endocrine neoplasm type 1 syndrome: Case report and systematic literature review. Clin Exp Med. 2018;18(4):585-93. https://doi.org/10.1007/s10238... PMid:29922966.
 
7.
Khaladkar SM, Bhatwal AS, Mahajan A, Goyal DS. Brown tumour of maxilla presenting as first manifestation of primary hyperparathyroidism due to parathyroid adenoma–Case report with radiological review. Int J Health Sci Res. 2015;5(10):410-6.
 
8.
Artul S, Bowirrat A, Yassin M, Armaly Z. Maxillary and frontal bone simultaneously involved in brown tumor due to secondary hyperparathyroidism in a hemodialysis patient. Case Rep Oncol Med. 2013;2013:909150. https://doi.org/10.1155/2013/9... PMid:24024056 PMCid:PMC3760209.
 
9.
Aghaghazvini L, Sharifian H, Rasuli B. Primary hyperparathyroidism misdiagnosed as giant cell bone tumor of maxillary sinus: A case report. Iran J Radiol. 2016;13(1):e13260. https://doi.org/10.5812/iranjr... PMid:27127572 PMCid:PMC4841893.
 
eISSN:2516-3507
Journals System - logo
Scroll to top