Association of Mean Platelet Volume With The Degree of Retinopathy in Patients with Diabetes Mellitus
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Department of Ophthalmology, University of Ataturk, School of Medicine, Erzurum, Turkey.
Department of Internal Medicine, University of Ataturk, School of Medicine, Erzurum, Turkey.
Online publication date: 2009-04-15
Publication date: 2009-04-15
Corresponding author
Orhan Ateş
Assistant Prof. Dr. Ataturk University, Medical School, Department of Ophthalmology Erzurum, Turkey
Eur J Gen Med 2009;6(2):99–102
Aim: We investigated the association of mean platelet volume (MPV) with the degree of retinopathy in patients with diabetes mellitus (DM). Methods: Ninety patients with diabetic retinopathy (DRP) and 30 healthy individuals were included in the study. Diabetic patients included 30 background, 30 non-proliferative and 30 proliferative diabetic retinopathy cases. Complete blood count, intra- and intergroup comparisons of MPV values were performed. Results: Mean values for MPV in patients with background, nonproliferative and proliferative DRP were 7.76±0.72 fL, 7.94±0.61 fL and 8.18±0.89 fL, respectively. MPV values of patients with background DRP was not significantly different from that of the control group and patients with non-proliferative and proliferative DRP as well. However, MPV values of patients with proliferative DRP were significantly higher than the values of control group (p< 0.05). A significant correlation was found between the degree of retinopathy and mean values of MPV in diabetic patients (r= 0.214, p< 0.05). Conclusions: We found an association between the degree of retinopathy and mean values of MPV. This finding suggests a role for platelets in the pathogenesis of vascular complications and that mean platelet volume would be useful in monitoring the disease progression.