ORIGINAL ARTICLE
CAN CALCIUM AND SODIUM CHANNEL BLOCKERS ATTENUATE HEMODYNAMIC RESPONSES TO ENDOTRACHEAL INTUBATION?
 
More details
Hide details
1
Rajiv Gandhi University, Mysore Medical College, Krishna Rajendra Hospital and Cheluvamba Hospital, India
 
2
Roosevelt University, Department of Biological, Physical Sciences, Chicago, USA
 
 
Online publication date: 2008-10-15
 
 
Publication date: 2008-10-15
 
 
Corresponding author
Sathees Beladakere Channaiah Chandra   

Associate Professor of Biology/Genetics, Department of Biological, Chemical and Physical Sciences, Roosevelt University, 430 S Michigan Avenue, Chicago, IL 60605 USA Phone: 8476197968, Fax: 8476198555
 
 
Eur J Gen Med 2008;5(4):198-207
 
KEYWORDS
ABSTRACT
Aim: Direct laryngoscopy and endotracheal intubation following induction of anesthesia almost always triggers powerful cardiovascular responses. The purpose of this study was to investigate the efficacy of diltiazem (calcium channel blocker), lidocaine (sodium channel blocker) and a combination of these two drugs in the attenuation of circular responses to endotracheal intubation in normotensive patients. Methods: 120 Patients were randomly assigned to one of the following four groups. Group I received a single 0.2 mg/kg IV bolus of diltiazem 1 minute prior to laryngoscopy and intubation (n=30), Group II received a single 1.5 mg/kg IV bolus of lidocaine (n=30) 3 minutes prior and Group III received combination of these two drugs 1 minute prior to laryngoscopy and intubation (n=30). Group IV served as the control and received a single 5 mL IV bolus of normal saline. Changes in heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were measured and then compared within and between groups. Rate pressure product (RPP) was calculated and evaluated as well. Results:Either diltiazem or lidocaine alone blunts unwanted hemodynamic responses to intubation. However, significantly less circulatory responses were experienced by patients receiving both than those receiving either lidocaine or diltiazem alone. Conclusion: Given the difference in the pharmacological mechanisms of these two drugs, the prophylactic therapy with combination of diltiazem+lidocaine is significantly more effective than any one alone for attenuating hemodynamic changes to laryngoscopy and tracheal intubation, without producing increased risk of hypertension.
eISSN:2516-3507
Journals System - logo
Scroll to top