Coagulation, fibrinolytic and cytokines parameters response to weight reduction in obese subjects
More details
Hide details
Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, Saudi Arabia
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Saudi Arabia
Online publication date: 2017-12-29
Publication date: 2018-01-03
Eur J Gen Med 2018;15(1):27–32
Background: Obesity is a major risk factor for developing cardiovascular disorders due to increased platelets count and platelets activation. Objective: The aim of this study was to measure the influence of weight loss on the coagulation and fibrinolysis parameters among obese patients.

Material and Methods:
One hundred obese subjects of both genders (mean age 46.72± 3.13 year) selected from the Internal Medicine Department at King Abdul Aziz University Teaching Hospital, their body mass index (BMI) ranged from 32 to 36 Kg/m2. Participants enrolled randomly into two study groups; the first group (A) received aerobic exercises and diet regimen for three months, while the second group (B) received no exercise training or diet regimen for three months.

Mean values of von Willbrand factor antigen (vWF-Ag), fibrinogen, plasminogen activator inhibitor-1 antigen (PAI-1:Ag) and plasminogen activator inhibitor-1 activity (PAI-1:Ac), tumor necrotic factor-alpha (TNF-α), Interleukin – 6 (IL-6) and body mass index (BMI), while the mean values of partial thromboplastin time (PTT), prothrombin time (PT), tissue plasminogen activator antigen (tPA:Ag) and tissue plasminogen activator activity (tPA:Ac) increased significantly after 3 months in group (A) as a result of weight reduction program. However, the mean values of all investigated parameters of group (B) had no significant changes. Moreover, comparison between both groups had statistical significant differences in all investigated parameters at the end of the study (P<.05).

weight reduction program modulates systemic inflammation, fibrinolytic and coagulation of obese subjects.

Anfossi G, Russo I, Trovati M. Platelet dysfunction in central obesity .Nutrition, Metabolism and Cardiovascular Diseases. 2009;19:440-9.
Després J. Cardiovascular disease under the influence of excess visceral fat. Crit Pathw Cardiol. 2007;6:51–9.
Samocha-Bonet D, Justo D, Rogowski O, Saar N, Abu-Abeid S, Shenkerman G. Platelet counts and platelet activation markers in obese subjects. Mediators Inflamm. 2008;10:8341-53.
Ritchie S, Connell J. The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metab Cardiovasc Dis. 2007;17:319–26.
Galic S, Oakhill J, Steinberg G. Adipose tissue as an endocrine organ. Mol Cell Endocrinol. 2010;316:129–39.
Vilahur G, Badimon L. Antiplatelet properties of natural products. Vascular Pharmacology. 2013;59: 67–75.
Hulsmans M, Holvoet P. The vicious circle between oxidative stress and inflammation in atherosclerosis. J Cell Mol Med. 2010;14:70–8.
Surmi B and Hasty A. The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue. Vascul Pharmacol. 2010;52:27–36.
Vasconcelos E, Degasperi G, de Oliveira H, Vercesi A, de Faria E, Castilho L. Reactive oxygen species generation in peripheral blood monocytes and oxidized LDL are increased in hyperlipidemic patients. Clin Biochem. 2009;42:1222–7.
Peng J, Friese P, Wolf R, Harrison P, Downs T, Lok S. Relative reactivity of platelets from thrombopoietin- and interleukin-6-treated dogs. Blood. 1996;87:4158–63.
Lou J, Donati Y, Juillard P, Giroud C, Vesin C, Mili N. Platelets play an important role in TNF-induced microvascular endothelial cell pathology. Am J Pathol. 1997;151:1397–1405.
DeSouza C, Jones P, Seals D. Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women. Arterioscler Thromb Vasc Biol. 1998;18:362–8.
Murakami T, Horigome H, Tanaka K, Nakata Y, Ohkawara K, Katayama Y, Matsui A. Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity. Thrombosis Research. 2007;119:45-53.
Jahangard T, Torkaman G, Ghoosheh B, Hedayati M, Dibaj A. The effect of short-term aerobic training on coagulation and fibrinolytic factors in sedentary healthy postmenopausal women. Maturitas. 2009;64:223-7.
Ades P, Savage P, Toth M, Schneider D, Audelin M, Bunn J. The influence of obesity and consequent insulin resistance on coronary risk factors in medically treated patients with coronary disease. Int J Obes. 2008;32:967–74.
Hamdy O, Ledbury S, Mullooly C, Jarema C, Porter S, Ovalle K. Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care. 2003;26:2119–25.
National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults—the evidence report. Obes Res. 1998;6(Suppl 2):51S–209S.
Lee I, Rexrode K, Cook N, Manson J, Buring J. Physical activity and coronary heart disease in women: “is no pain, no gain” passé?. JAMA. 2001;285(11):1447–54.
Szymanski L, Kessler C, Fernhall B. Relationship of physical fitness, hormone replacement therapy, and hemostatic risk factors in postmenopausal women. J Appl Physiol. 2005;98(4):1341–8.
Barbeau P, Litaker M, Woods K, Lemmon C, Humphries M, Owens S. Hemostatic and inflammatory markers in obese youths: effects of exercise and adiposity. J Pediatr. 2002;141:415–420.
Svendsen O, Hassager C, Christiansen C, Nielsen J, Winther K. Plasminogen activator inhibitor-1, tissue-type plasminogen activator, and fibrinogen: effect of dieting with or without exercise in overweight postmenopausal women. Arterioscler Thromb Vasc Biol. 1996;16:381–5.
Mavri A, Stegnar M, Krebs M, Sentocnik J, Geiger M, Binder B. Impact of adipose tissue on plasma plasminogen activator inhibitor-1 in dieting obese women. Arterioscler Thromb Vasc Biol. 1999;19:1582–7.
Piccone G, Fazio F, Giudice E, Grasso F, Caola G. Exercise-induced change in clotting times and fibrinolytic activity during official 1600 and 2000 meters trot races in standard horses. Acta Vet Brno. 2005;74:509–14.
Stratton J, Chandler W, Schwartz R. Effect of physical conditioning on fibrinolytic variables and fibrinogen in young and old healthy adults. Circulation. 1991;83(5):1692–7.
Saenko E, Yakhyaev A, Mikhailenko I, Strickland D, Sarafanov A. Role of low-density lipoprotein-related protein receptor in mediation of factor VIII catabolism. J Biol Chem. 1999;274(53):37685–92.
Paton C, Nagelkirk P, Coughlin A. Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down. Eur J Appl Physiol. 2004;92(3):328–33.
DeSouza C, Jones P, Seals D. Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women. Arterioscler Thromb Vasc Biol. 1998;18(3):362–8.
Stefanick M, Legault C, Tracy R. Distribution and correlates of plasma fibrinogen in middle-aged women: initial findings of the Postmenopausal Estrogen/Progestin Interventions (PEPI) study. Arterioscler Thromb Vasc Biol. 1995;15(12): 2085–93.
Krobot K, Hense H, Cremer P, Eberle V, Keil U. Determinants of plasma fibrinogen: relation to body weight, waist-to-hip ratio, smoking, alcohol, age, and sex: results from the second MONICA Augsburg Survey 1989–1990. Arterioscler Thromb. 1992;12(7):780–8.
Esposito K, Pontillo A, Di C. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA. 2003;289(14):1799–1804.
Reinher T, Stoffel-Wagner B, Roth C, Andler W. High-sensitive C-reactive protein, tumour necrosis factor α, and cardiovascular risk factors before and after weight loss in obese children. Metabolism. 2005; 54:1155–61.
Gallistatl S, Sudi K, Aigner R, Borkenstein M. Changes in serum interleukin-6 concentrations in obese children and adolescents during a weight reduction program. Int J Obes. 2001;25:1640–3.