ORIGINAL ARTICLE
Factors Associated with Early-onset Neonatal Sepsis in Children of Peruvian Military Personnel
 
More details
Hide details
1
Universidad Nacional de Cajamarca, Cajamarca, Peru
 
2
Sociedad Científica de Estudiantes de Medicina de Cajamarca, Universidad Nacional de Cajamarca, Cajamarca, Peru
 
3
Facultad de Medicina y Cirugía, Universidad Católica de Honduras, San Pedro Sula, Honduras
 
4
School of Nursing, Trinity Western University, Langley, BC, Canada
 
5
Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil
 
6
Universidad Continental, Lima, Peru
 
 
Online publication date: 2019-11-06
 
 
Publication date: 2019-11-06
 
 
Electron J Gen Med 2019;16(5):em156
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The risk factors for early-onset neonatal sepsis (EOS) are well known. However, they have still not been evaluated in children of military personnel, which are a special population.

Objective:
To determine factors associated with EOS in children of Peruvian military personnel in a hospital.

Materials and Methods:
This is an observational, analytical, and retrospective study that included neonates hospitalized in the Neonatal Unit of the Hospital Militar Central, Peru between 2009 and 2017. Data were compiled from clinical history and hospital stay records. Sepsis cases were cross-checked against other variables of interest via generalized linear models.

Results:
Out of a total of 2,371 included neonates, 114 neonates were diagnosed with EOS. There was an increased frequency of neonatal sepsis with longer neonatal hospital stay (adjusted prevalence ratio (aPR): 1.21; 95% confidence interval (CI): 1.15–1.28; p<0.001), greater gestational age (aPR: 1.03; 95% CI: 1.01–1.05; p =0.003), and development of urinary tract infection in pregnant women in the third trimester of pregnancy (aPR: 2.27; 95% CI: 1.39–3.73; p=0.003). In contrast, there was a lower incidence of neonatal sepsis in female neonates (aPR: 0.64; 95% CI: 0.42–0.99; p=0.044).

Conclusions:
The associated factors with EOS in children of Peruvian military personnel were sex, longer neonatal hospital stay, gestational age and development of urinary tract infection in pregnant women during the third trimester of pregnancy. The aforementioned information is significant in describing this neonate population.

 
REFERENCES (19)
1.
Cortese F, Scicchitano P, Gesualdo M, et al. Early and late infections in newborns: where do we stand? a review. Pediatr Neonatol. 2016;57(4):265-73. https://doi.org/10.1016/j.pedn... PMid:26750406.
 
2.
Wynn JL. Defining neonatal sepsis. Curr Opin Pediatr. 2016;28(2):135-40. https://doi.org/10.1097/MOP.00... PMid:26766602 PMCid:PMC4786443.
 
3.
Kimberlin DW, et al. Red Book 2015: 2015 Report of the Committee on Infectious Diseases, American Academy of Pediatrics. 2015.
 
4.
Chan GJ, Lee AC, Baqui AH, Tan J, Black RE. Risk of early-onset neonatal infection with maternal infection or colonization: a global systematic review and meta-analysis. PLoS Med. 2013;10(8):e1001502. https://doi.org/10.1371/journa... PMid:23976885 PMCid:PMC3747995.
 
5.
Gebremedhin D, Berhe H, Gebrekirstos K. Risk factors for neonatal sepsis in public hospitals of Mekelle city, North Ethiopia, 2015: unmatched case control study. PLoS One. 2016;11(5):e0154798. https://doi.org/10.1371/journa... PMid:27163290 PMCid:PMC4862626.
 
6.
Rojas Espinoza ES. Factores determinantes de sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, enero-diciembre 2012 [research work] [online]. Lima: Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana Escuela de Post-Grado; 2014. Available from: https://pdfs.semanticscholar.o... [Accessed 10 August 2019].
 
7.
Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018;6(3):223-30. https://doi.org/10.1016/S2213-....
 
8.
Wynn JL, Wong HR, Shanley TP, Bizzarro MJ, Saiman L, Polin RA. Time for a neonatal-specific consensus definition for sepsis. Pediatr Crit Care Med. 2014;15(6):523-8. https://doi.org/10.1097/PCC.00... PMid:24751791 PMCid:PMC4087075.
 
9.
Jiang Z, Ye GY. 1:4 matched case-control study on influential factor of early onset neonatal sepsis. Eur Rev Med Pharmacol Sci. 2013;17(18):2460-6. PMID: 24089224.
 
10.
Daniel Enrique RC. Factores de riesgo maternos asociados a sepsis neonatal temprana en prematuros en el servicio de neonatología del Hospital María Auxiliadora en el periodo enero- diciembre 2015 [dissertation] [online]. Lima: Universidad Ricardo Palma, Facultad de Medicina Humana; 2017. Available at: http://cybertesis.urp.edu.pe/b... [Accessed 30 October 2018].
 
11.
Pérez RO, Lona JC, Quiles M, Verdugo MÁ, Ascencio EP, Benítez EA. Early neonatal sepsis, incidence and associated risk factors in a public hospital in western Mexico. Rev Chilena Infectol. 2015;32(4):387-92. https://doi.org/10.4067/S0716-... PMID: 26436790.
 
12.
Coral Linares KM. Factores de riesgo asociados a sepsis neonatal precoz en el Hospital Vitarte durante el periodo 2011-2013 [research work] [online]. Lima: Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana Escuela de Post-Grado; 2014. Available from: https://pdfs.semanticscholar.o... [Accessed 30 October 2018].
 
13.
Jajoo M, Kapoor K, Garg LK, Manchanda V, Mittal SK. To study the incidence and risk factors of early onset neonatal sepsis in an out born neonatal intensive care unit of India. J Clin Neonatol. 2015;4(2)91-5. https://doi.org/10.4103/2249-4....
 
14.
Softić I, Tahirović H, Di Ciommo V, Auriti C. Bacterial sepsis in neonates: single centre study in a Neonatal intensive care unit in Bosnia and Herzegovina. Acta Med Acad. 2017;46(1):7-15. https://doi.org/10.5644/ama200... PMid:28605923.
 
15.
Ministry of Health of Peru. Guías nacionales de atención integral de la salud sexual y reproductiva. 2004. Available at: http://bvs.minsa.gob.pe/local/....
 
16.
Iyo Alberti FL. Controles prenatales y puntaje Apgar menor de 7 como factores determinantes de sepsis neonatal temprana. Hospital Nacional Dos de Mayo [research work]. Trujillo: Universidad Privada Antenor Orrego, Facultad de Medicina Humana Escuela Profesional de Medicina Humana; 2015. Available at: http://repositorio.upao.edu.pe... [Accessed 30 October 2018].
 
17.
Chan GJ, Lee AC, Baqui AH, Tan J, Black RE. Prevalence of early-onset neonatal infection among newborns of mothers with bacterial infection or colonization: a systematic review and meta-analysis. BMC Infect Dis. 2015;15:118. https://doi.org/10.1186/s12879... PMid:25886298 PMCid:PMC4364328.
 
18.
Wang ME, Patel AB, Hansen NI, Arlington L, Prakash A, Hibberd PL. Risk factors for possible serious bacterial infection in a rural cohort of young infants in central India. BMC Public Health. 2016;16(1):1097. https://doi.org/10.1186/s12889... PMid:27760543 PMCid:PMC5070173.
 
19.
Guidet B, Maury E. Sex and severe sepsis. Crit Care. 2013;17(3):144. https://doi.org/10.1186/cc1269... PMid:23680409 PMCid:PMC3672659.
 
eISSN:2516-3507
Journals System - logo
Scroll to top