Glycemic control in children with type 1 diabetes: Insulin pump therapy versus multiple daily injections
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Department of Internal Medicine, University Medical Center, Astana, KAZAKHSTAN
Department of Pediatrics, University Medical Center, Astana, KAZAKHSTAN
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, KAZAKHSTAN
Department of Ophthalmology, Kazakh National Medical University named after S. D. Asfendiyarov, Almaty, KAZAKHSTAN
Department of Internal Medicine, Municipal Children’s Hospital №2, Astana, KAZAKHSTAN
Family Medicine Clinic, West Kazakhstan Marat Ospanov Medical University, Aktobe, KAZAKHSTAN
Regional Children’s Hospital, Shymkent, KAZAKHSTAN
Department of Medicine, School of Medicine, Nazarbayev University, Astana, KAZAKHSTAN
Publication date: 2024-03-25
Electron J Gen Med 2024;21(2):em580
While many studies compared multiple daily injections (MDI) and insulin pump therapy on various clinical outcomes, the results remain inconclusive. This multicenter retrospective cohort study included 175 patients and aimed to evaluate the effects of different insulin therapy methods on various clinical outcomes, including hemoglobin A1c (HbA1c), total daily insulin dosage, body mass index, glomerular filtration rate, in pediatric patients with type 1 diabetes. In a linear mixed-effects regression analysis, a statistically significant interaction between time and treatment type onHbA1c was found. It suggested significantly higher reduction of HbA1c values between 12-month visit and baseline in the group receiving MDIs compared to insulin pump therapy. Patients using MDIs observed higher reduction of HbA1c levels and lower total daily insulin dose relative to insulin pump therapy group. Other changes of clinical indicators were the same for group of patients. Various studies report controversial results on long term effects of these treatments on HbA1c values necessitating large population-based cohort studies in this field.
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