ORIGINAL ARTICLE
Macrolide-Lincosamide-Streptogramin B Resistance Phenotypes in Staphylococcus Aureus
 
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1
Mevlana University, Faculty of Medicine, Department of Medical Microbiology, Konya, Turkey
 
2
Canakkale Onsekiz Mart University, Faculty of Medicine, Department of Medical Microbiology, Canakkale, Turkey
 
3
Erciyes University, Faculty of Medicine, Department of Medical Microbiology, Kayseri, Turkey
 
 
Publication date: 2014-10-15
 
 
Corresponding author
Süleyman Durmaz   

Mevlana University, Faculty of Medicine, Department of Medical Microbiology, Konya, 42003 Turkey
 
 
Eur J Gen Med 2014;11(4):217-220
 
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ABSTRACT
Staphylococcus aureus is one of the most frequently isolated pathogens in community and hospital-acquired infections. Macrolide-lincosamide-streptogramin B (MLSB) group antibiotics have frequently been preferred. In this study, it was aimed to determine MLSB group antibiotics resistance phenotypes observed in S. aureus strains. A total of 182 S. aureus strains were included in the study. Methicillin resistance was assessed using the cefoxitin (30μg) disc, MLSB resistance phenotypes were assessed using D zone test with erythromycin (15μg) and clindamycin (2μg) discs according to the Clinical and Laboratory Standards Institute (CLSI) recommendations. Of the strains included in the study, 38 (20.9%) methicillin-resistant S.aureus (MRSA) and 144 (79.1%) methicillin-susceptible S.aureus (MSSA) were identified. MLSB resistance phenotype was found in 65 (35.7%) strains. MLSB resistance was found 84% in MRSA strains and 23% in MSSA strains: There was statistically significant between MRSA and MSSA strains. Constitutional MLSB resistance was found higher in MRSA strains (71%) and however, in MSSA strains was higher inducibleMLSB resistance (16.5%). It is suggested that, using the D test method in routine antibiotic susceptibility testing and determining resistance phenotypes in microbiology laboratories is the right approach and may play an important role in the prevention of treatment failure according to the substantial proportion of inducible resistance MLSB resistance observed.
eISSN:2516-3507
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