Surgery is the crucial modality of management in the multidisciplinary care of breast cancer. Without surgery the outcome of treatment is complicated and sub-optimal. The oncologists face dilemma when patient refuse for surgery or not operable due to patients medical condition. Here we describe two post-menopausal women with operable breast cancers those refused surgery. We managed these patients with induction chemotherapy, radical radiotherapy and hormonal therapy. Their serial radiological evaluation revealed complete disappearance of primary breast tumor and axillary lymph nodes at the end of 88 and 69 months post treatment with good cosmesis. Conservative management may be an option among post-menopausal women with operable breast cancers those refuse surgery. The controversial management of above cases has been discussed with review of literature.