Pattern of sensitivity to respiratory allergens in patients with sinonasal polyposis
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Associated Prof of otolaryngology, Hearing research center, Ahvaz Jundishapur university of medical sciences, Ahvaz, Iran
Assistant Prof of Clinical Immunology and allergy, Ahvaz jundishapur university of medical sciences, Ahvaz, Iran
Otolaryngologist, Hearing research center, Ahvaz jundishapur university of medical sciences, Ahvaz, Iran
Online publication date: 2018-12-28
Publication date: 2019-04-22
Electron J Gen Med 2019;16(2):em134
Background & Aim:
Sinonasal polyposis is the existence of a nontumoral mass inside the nose and paranasal sinuses which can lead to nasal obstruction and other annoying problems for the patient. Since the pathogenesis of this disease and the involved factors in severity of symptoms has remained unknown, the present study has proceeded to evaluate the Pattern of sensitivity to respiratory allergens in patients with sinonasal polyposis.

Methods & Materials:
This observational study was a descriptive cross sectional study evaluating 77 patients with sinonasal polyposis from May 2014 to April 2015. The demographic data, history of signs related to allergy in the patient and his/her family was collected and recorded. The concentrations of serum specific IgE were measured.

Seventy-seven patients with sinonasal polyposis including 25 women (32.5%) with average age of 42.48± 13.43 years and 52 men (67.5%) with average age of 43.40±13.57 years were evaluated. The present study showed that the result of allergen test was positive in 32 men (61.54%) and 20 women (80%). Also, the results showed that the allergen test was negative in 25 patients (32.47%), in 6 cases (7.79%) only one allergen was positive, the results of allergen test in 46 patients (59.74%), for at least two allergens were positive. The highest numbers of positive allergens in a patient was 28. The most allergen observed in patients included plane tree 23 (29.9%), Kochia 22 (28.6%), Alternaria alternaria 20 (26%), Pigweed 20 (26%).

Our results indicate that there are correlations between aeroallergen and clinical signs in individuals with sinonasal polyposis, and the possibility of allergic background can be considered in encountering with such patients, although these cases need specific studies with larger sample sizes.

Bachert C, Van Zele T, Gevaert P, De Schrijver L, Van Cauwenberge P. Superantigens and nasal polyps. Current allergy and asthma reports 2003,3:523-31. https://doi.org/10.1007/s11882... PMid:14531975.
Esmatinia F. Recurrent sinonasal polyposis after the endoscopic sinus surgery. Reviews in Clinical Medicine 2014,1:86-92.
Kalpana Kumari M, Mahadeva K. Polypoidal lesions in the nasal cavity. Journal of clinical and diagnostic research: JCDR 2013,7:1040.
Wilson KF, McMains C, Orlandi RF. The association between allergy and chronic Rhinosinusitis with and without nasal polyposis: an evidence-based review with recommendations. Int Forum Allergy Rhinol 2014;4:93-103. https://doi.org/10.1002/alr.21... PMid:24395734.
Nikakhlagh S, Rahim F, Saki N, Mohammadi H, Maliheh YM (2012) Antrochoanal polyps: report of 94 cases and review the literature. Niger J Med 21(2):156-9. PMid:23311182.
Newton JR, Ah-See KW. A review of nasal polyposis. Therapeutics and clinical risk management 2008,4:507. https://doi.org/10.2147/TCRM.S....
Ogunleye A, Fasunla A. Nasal polyps-clinical profile and management in Ibadan, Nigeria. Nigerian Journal of Surgical Research 2005,7:164-167.
Settipane GA. Epidemiology of nasal polyps. In: Allergy and Asthma Proceedings: OceanSide Publications, Inc; 1996. pp. 231-6. https://doi.org/10.2500/108854....
Hulse K, Stevens W, Tan B, Schleimer R. Pathogenesis of nasal polyposis. Clinical & Experimental Allergy 2015;45:328-46. https://doi.org/10.1111/cea.12... PMid:25482020 PMCid:PMC4422388.
Parnes SM, Chuma AV. Acute effects of antileukotrienes on sinonasal polyposis and sinusitis. Ear, nose & throat journal 2000;79:18. PMid:10665187.
Fokkens W, Lund V, Mullol J. European position paper on rhinosinusitis and nasal polyps 2007. Rhinology. Supplement 2006:1-136.
Orlandi RR, Kingdom TT, Hwang PH, et al. International consensus statement on allergy and rhinology: rhinosinusitis. Int Forum Allergy Rhinol 2016;6:22-209. https://doi.org/10.1002/alr.21... PMid:26889651.
Collins M, Pang YT, Loughran S, Wilson J. Environmental risk factors and gender in nasal polyposis. Clinical Otolaryngology & Allied Sciences 2002;27:314-7. https://doi.org/10.1046/j.1365....
Ahmad MJ, Ayeh S. The Epidemiological and Clinical Aspects of Nasal Polyps That Require Surgery. Iranian Journal Of Otorhinolaryngology 2012,2:76-7.
Shakurnia AH, Assarehzadegan MA, Mozaffari A, Shakerinejad G, Maneshdavi N, Amini A, et al. Prevalence of aeroallergens in allergic patients in Ahvaz. 2013.
Kashef S, Kashef MA, Eghtedari F. Prevalence of aeroallergens in allergic rhinitis in Shiraz. Iranian Journal of Allergy, Asthma and Immunology 2003,2:185-8. PMid:17301378.
Assarehzadegan MA, Shakurnia A, Amini A. The most common aeroallergens in a tropical region in Southwestern Iran. World Allergy Organization Journal 2013;6:7. https://doi.org/10.1186/1939-4... PMid:23663517 PMCid:PMC3651228.
Sabirov A, Hamilton RG, Jacobs JB, Hillman DE, Lebowitz RA, Watts JD. Role of local immunoglobulin E specific for Alternaria alternata in the pathogenesis of nasal polyposis. The Laryngoscope 2008;118:4-9. https://doi.org/10.1097/MLG.0b... PMid:17989579.
Fereidouni M, Hossini RF, Azad FJ, Assarezadegan MA, Varasteh A. Skin prick test reactivity to common aeroallergens among allergic rhinitis patients in Iran. Allergologia et immunopathologia 2009;37:73-9. https://doi.org/10.1016/S0301-....
Nikakhlagh S, Ghafourian-Boroujerdnia M, Saki N, Soltan-Moradi MR, Rahim F. Immunologic factors in patients with chronic polypoid sinusitis. Niger J Med.
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