Preoperative Serum IL-6 Levels: Clinical Importance in Gastric Carcinoma with Lymph Node Metastasis
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Yuzuncu Yıl University Medical Faculty, Van, Turkey
İstanbul University, Cerrahpasa Medical Faculty, İstanbul, Turkey
Okmeydanı Training Hospital, Department of Endocrinology, İstanbul, Turkey
Haseki Training Hospital, II. General Surgery Department, İstanbul, Turkey
Publication date: 2010-10-12
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Özgür Kemik   

Department of General Surgery, Yuzuncu Yıl University Medical Faculty, Van, Turkey
Eur J Gen Med 2010;7(4):410-413
Aim: The interleukin-6 (IL-6) pathway is one of the mechanisms that link inflammation and angiogenesis. The purpose of this study was to investigate the preoperative serum levels of IL-6 in gastric carcinoma with lymph node metastasis, and to correlate them with disease status. Method: A total of 100 patients who underwent gastrectomy were enrolled in this study. Serum levels of IL-6 were assessed enzyme linked immunosorbent assay (ELISA). Histological findings included tumor size, depth of tumor invasion, lymph node (LN) metastasis, and TNM stage. Result:Increases in cancer invasion and staging are generally associated with increases in preoperative serum IL-6 levels. IL-6 levels were correlated with invasion depth (p<0.001), LN metastasis (p<0.001), and TNM stage. The presence of peritoneal seeding metastasis is associated with IL-6 levels (p<0.001). Conclusion: Preoperative serum IL-6 levels might be markers of tumor invasion, LN metastasis, and TNM stage. These results suggest that IL-6 levels are potential molecular markers that predict lymphatic involvement in gastric carcinoma.
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