Relation between airway cellular and bacterial findings and severity of COPD exacerbations: A multicentric study
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Department of Chest Diseases, Al-Azhar University, Cairo, EGYPT
Department of Chest Diseases, Ain Shams University, Cairo, EGYPT
Department of Clinical Pathology, Al-Azhar University, Cairo, EGYPT
Department of Chest Diseases, Zagazig University, Zagazig, EGYPT
Online publication date: 2024-02-12
Publication date: 2024-03-01
Electron J Gen Med 2024;21(2):em573
To evaluate the relationships between sputum and bronchoalveolar lavage (BAL) cellular and bacterial findings and severity of exacerbation of chronic obstructive pulmonary disease (ECOPD).

Patients & methods:
A cross-section study was conducted on 307 patients with ECOPD. They underwent sputum and BAL inflammatory cell count and bacterial culture.

Patients with severe ECOPD have significantly higher neutrophils percentage (neut.%), lower lymphocytes percentage (lymph.%), lower eosinophils percentage (eosin.%) and higher neutrophil/lymphocyte ratio (NLR) as compared to patients with mild ECOPD. It was also shown that patients with severe ECOPD had significantly higher BAL neut.%, lower lymph.%, lower eosin.%, and higher NLR as compared to the other two subgroups. Also, patients with severe ECOPD have significantly higher frequency of cases with monomicrobial (71.30% vs. 36.10%) and polymicrobial (21.25% vs. 2.10%) growths in comparison to patients with mild ECOPD.

Cellular and bacterial findings in sputum and BAL are related to severity of ECOPD.

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