Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome and Malignancy
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Yüzüncü Yıl University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Van, Turkey
Online publication date: 2004-04-15
Publication date: 2004-04-15
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Mehmet Sayarlıoğlu   

Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Araştırma Hastanesi, İç Hastalıkları AD, Romatoloji BD. 65200 Van, Turkey Telephone:+90 532 2239020 Fax:+90 432 2155051
Eur J Gen Med 2004;1(2):3-5
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a definite subset of the seronegative symmetrical polyarthritis of the aged, characterized by dramatic pitting edema of the hands, male predominance, old age and exquisite response to corticosteroids. RS3PE syndrome is a rare but well-defined syndrome known to be associated with solid tumors and haematologic malignancies. Recent research has shown that it is not a specific entity but rather a syndrome that can represent the inaugural form of various types of rheumatic disease and neoplastic conditions of the elderly. A thorough examination in elderly patients with RS3PE syndrome, and heightened suspicion of potential underlying malignant disease is necessary.
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