Serum Level of Soluble Vascular Adhesion Molecule 1 in Patients with Rectal Cancer
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Yuzuncu Yıl University Medical Faculty, Van, Turkey
University of Istanbul, Cerrahpasa Medical Faculty, Istanbul, Turkey
Okmeydanı Education and Training Hospital, Department of Endocrinology, İstanbul, Turkey
Haseki Education and Training Hospital, II. General Surgery, İstanbul, Turkey
Publication date: 2011-04-11
Corresponding author
Özgür Kemik   

Department of General Surgery, Yuzuncu Yıl University Medical Faculty, Van, Turkey
Eur J Gen Med 2011;8(2):105-109
Aim: Vascular adhesion molecule 1 (VCAM-1) plays an important role in solid tumor enlargement and/or metastases. This study evaluated the clinical significance of measuring serum levels of soluble VCAM-1 in rectal cancer and aimed to clarify the biologic significance of its local expression. Method: Serum was collected from 90 patients with rectal cancer and 40 healthy volunteers. Cancer tissue was collected from 84 patients. The level of soluble VCAM-1 in serum and cancer tissue was measured enzyme linked immunosorbent assay. Result: The mean soluble VCAM-1 level in patients was significantly higher than that in control subjects. Elevated serum soluble VCAM-1 was significantly associated with clinicopathologic paramaters such as tumor size, lymph node metastasis, distant metastasis, and poor prognosis. The prognosis for stage 2 patients positive for soluble VCAM-1 level was comparable to that for stage 3 patients. In addition, the serum level of soluble VCAM-1 level was not found correlation with the cancer tissue level. Conclusion: The preoperative level of soluble VCAM-1 level reflected disease progression and was a sensitive biomarker for rectal cancer.
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