Stem Cells and Myocardial Regeneration
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Bio-Cellular Research Organization, Barksdale Professional Center, Newark, DE, USA
Online publication date: 2004-10-15
Publication date: 2004-10-15
Corresponding author
E. Michael Molnar   

Bio-Cellular Research Organization, 113 Barksdale Professional Center, Newark, DE 19711, USA
Eur J Gen Med 2004;1(4):7-14
Cardiomyocytes lose their ability to proliferate after birth and so heart muscle fibers cannot regenerate. For that reason myocardial injury, such as myocardial infarction (MI), heals by replacement of contractile heart muscle fibers by fibrotic tissue scar, which not only cannot participate in pumping of blood, it does not even contribute to passive mechanics of heart. Massive loss of cardiomyocytes after MI is a common cause of heart failure (HF), which is a consequence of many other cardiovascular diseases, and serious public health problem.
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