ORIGINAL ARTICLE
THE EFFECT OF ANTIOXIDANT CAFFEIC ACID PHENETHYL ESTER (CAPE) ON SOME ENZYME ACTIVITIES IN CISPLATIN-INDUCED NEUROTOXICITY IN RATS
 
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1
Gaziosmanpaşa University, Faculty of Medicine, Department of Anatomy, Tokat, Turkey
 
2
Akyurt Integrated Unit of Ankara Numune Education and Research Hospital, Division of Biochemistry, Ankara, Turkey
 
3
Gaziosmanpaşa University, Faculty of Medicine, Department of Biochemistry, Tokat, Turkey
 
4
Gaziosmanpaşa University, Faculty of Medicine, Department of Physiology, Tokat, Turkey
 
 
Online publication date: 2006-10-15
 
 
Publication date: 2006-10-15
 
 
Corresponding author
Birsen Özyurt   

Gaziosmanpasa University, Faculty of Medicine, Department of Anatomy, Tokat, TURKEY Tel: 903562129500, Fax: 903562129417
 
 
Eur J Gen Med 2006;3(4):167-172
 
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ABSTRACT
Aim: Neurotoxicity is the next common side effect of cisplatin (CDDP)-based chemotherapeutics following nephrotoxicity. We investigated the effect of CDDP on some brain metabolic enzyme activities such as hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH), and malate dehydrogenase (MDH) in an experimental model of CDDP toxicity, and examined the protective role of Caffeic acid phenethyl ester (CAPE), a phenolic antioxidant derived from the honeybee propolis, on the enzyme activities mentioned above. Methods: Female Wistar albino rats were divided into three groups: sham operation group (n:6), CDDP group (n:9), and CAPE + CDDP group (n:8). All the chemicals used were applied intraperitoneally. HK, G6PD, LDH, and MDH activities were determined spectrophotometrically in the brain supernatant at the end of the surgical procedures. Results: There were decreased G6PD activities and increased MDH activities in CDDP group compared to control group (p<0.05, p<0.05). LDH activities were increased in CAPE+CDDP group compared to CDDP group (p<0.001). Conclusion: These results provide a new point of view on the glucose metabolizing enzymes of brain tissue affected from CDDP and the protective effects of CAPE on these enzymes.
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