The effect of telithromycin on inflammatory markers in chronic obstructive pulmonary diseases
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Konya Training and Research Hospital, Pulmonology Department, Konya, Turkey
Konya Training and Research Hospital, Microbiology Department, Konya, Turkey
Selçuk University, Meram Medical Faculty, Department of Pulmonary Medicine, Konya, Turkey
Online publication date: 2009-10-15
Publication date: 2009-10-15
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Taha Bekçi   

Konya Eğitim Araştırma Hastanesi Göğüs Hastalıkları Servisi Konya
Eur J Gen Med 2009;6(4):218-222
Aim: To evaluate the anti-inflammatory effect of telithromycin on sputum interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) levels in patient with chronic obstructive pulmonary diseases (COPD). Methods: Thirty four patients with mild to moderate COPD were enrolled in this prospective, single center, double-blind, placebo controlled study. Subjects received either telithromycin or placebo for 10 days. Before and after treatment period spirometric tests, arterial blood gas analyses were performed, sputum samples were taken for measurement of sputum inflammatory markers, and sputum was induced. Results: There was no statistical difference in baseline clinical or laboratory parameters between groups. After the treatment, the induced sputum IL-8, TNF-α, MPO levels is similar compared with pretreatment levels. Conclusion: In this study, anti-inflammatory effects of telithromycin in stable COPD patients were not demonstrated. Further studies are needed to determine the clinical significance of these findings.
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