Two Cases of Hiccups due to Gastroesophageal Reflux Disease
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Süleyman Demirel University, School of Medicine, Department of Gastroenterology, Isparta, Turkey
Online publication date: 2009-10-15
Publication date: 2009-10-15
Corresponding author
Erkan Cüre   

Suleyman Demirel University School of Medicine Department of Internal Medicine Isparta/Turkey 32100 Phone: +90 246 2112651 Fax: +90 246 2371758
Eur J Gen Med 2009;6(4):262-264
Hiccup is a spasmodic, involuntary contraction of the inspiratory muscles, associated with delayed, abrupt glottic closure, causing a peculiar sound. There are numerous causes of hiccup, including diseases of the gastrointestinal tract. Hiccup is reported to represent an atypical manifestation of the gastroesophageal reflux disease (GERD). We report two cases with hiccup due to GERD. Endoscopic examinations showed esophagitis, Los Angeles class grade A and B, in two cases whose hiccups were improved by proton pump inhibitors (PPI). Hiccup is atypical symptom of GERD. If hiccup is due to GERD, then it may be improved with ppi therapy.
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