Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor with tendency for local recurrence. Here we report a case of giant cell tumor of the right sided distal radius treated by en-bloc resection and reconstruction arthroplasty using autogenous non-vascularized ipsilateral proximal fibular graft. Early radiological union at host-graft junction was achieved at 12 weeks and solid incorporation with callus formation was observed at 20 weeks. Functional range of motion of the wrist was 20 degrees dorsiflexion and 20 degrees palmerflexion. Grip strength was moderate. Soft tissue recurrence and fibulo-carpal subluxation was not observed. Reconstruction arthroplasty of wrist following en-blocresection of GCT of the distal radius with non-vascularized proximal fibular graft was found useful in preserving the movements and functions as well as stability of the wrist.