Disulfiram Ethanol Reaction with Ischemic Stroke
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J.S.S.Medical College,J.S.S.University,Mysore, Karnataka, India
Publication date: 2014-07-15
Corresponding author
M Suresh Babu
Associate Professor of Medicine, JSS Medical College, JSS University, Mysore, Karnataka, India
Eur J Gen Med 2014;11(3):190-192
Disulfiram (tetraethylthiuram disulfide) has been used since decades in the treatment of alcohol addiction. It causes aversive behaviour towards alcohol due to Disulfiram Ethanol Reaction (DER). The classical DER includes flushing, sweating, tremors, nausea, vomiting, tachycardia, hypotension and restlessness. Complete recovery is the usual outcome in clinical settings. Life threatening reactions are rare but sometimes occur. Rare complications include shock, myocardial ischemia, hypertension, bronchospasm and methemoglobinemia. We present here a very rare case of ischemic stroke in a hemodynamically stable patient, which developed secondary to disulfiram–ethanol reaction. To the best of our knowledge, this is the first such reported case in literature.
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