Exploring the current status and trends of research on Langerhans Cell Sarcoma: A bibliometric analysis
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College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA
Deanship of Library Affairs, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA
Department of Medicine, Dow University of Health Sciences, Karachi, PAKISTAN
Gad and Birgit Rausing Library, Lahore University of Management Sciences, Lahore, PAKISTAN
Online publication date: 2023-05-25
Publication date: 2023-09-01
Electron J Gen Med 2023;20(5):em514
Langerhans cell sarcoma (LCS) is a highly malignant neoplasm exhibiting aggressive clinical behavior. In this study, we aimed to explore the current status and trends of research on LCS by doing a bibliometric analysis. Data on LCS were retrieved from the Web of Science database and a bibliometric analysis was conducted to measure the impact of publications, authors, organizations, and countries. Different software packages, including BiblioAnalytics, Bibliomaster, MS Excel, MS Access, VOSviewer, Biblioshiny, Power BI, and an online visualization platform were used for analysis and visualization in the present study. A total of 96 publications were included in the present bibliometric analysis. Authors “Lebbe C”, “Lorillon G”, “Mourah S”, and “Tazi A” received the highest number of citations, and the journal “Histopathology” received the highest number of citations. The outstanding organization was the Mayo Clinic in the USA with the highest number of 5 publications and the highest number of 175 citations. Japan and the USA were the outstanding countries that contributed to the research on LCS. Current literature on LCS is minimal, which stresses the need for more research productivity, especially within areas regarding diagnosis and immunohistochemical staining with CD markers for this pathology.
Bonetti F, Knowles DM, Chilosi M, et al. A distinctive cutaneous malignant neoplasm expressing the langerhans cell phenotype. Synchronous occurrence with B-chronic lymphocytic leukemia. Cancer. 1985;55(10):2417-25.<2417::AID-CNCR2820551020>3.0.CO;2-9 PMid:3886125.
Hossfeld DK. World Health Organization classification of tumours: Pathology and genetics of tumours of haematopoietic and lymphoid tissues (Book Review). Ann Oncol. 2002;13(3):490.
Sagransky MJ, Deng AC, Magro CM. Primary cutaneous langerhans cell sarcoma: A report of four cases and review of the literature. Am J Dermatopathol. 2013;35(2):196-204. PMid: 23051626.
Ferringer T, Banks PM, Metcalf JS. Langerhans cell sarcoma. Am J Dermatopathol. 2006;28(1):36-9. PMid:16456323.
Chung W Do, Im SA, Chung NG, Park GS. Langerhans cell sarcoma in two young children: Imaging findings on initial presentation and recurrence. Korean J Radiol. 2013;14(3):520-4. PMid:23690723 PMCid:PMC3655310.
Lauritzen AF, Ralfkiaer E. Histiocytic sarcomas. Leuk Lymphoma. 1995;18(1-2):73-80. PMid:8580832.
Lili M, Shoujing Y. Primary cutaneous langerhans cell sarcoma: Report of a case. Chinese J Pathol. 2021;50(3): 271-3. PMid: 33677899.
Ronen S, Keiser E, Collins KM, et al. Langerhans cell sarcoma involving skin and showing epidermotropism: A comprehensive review. J Cutan Pathol. 2021;48(4):547-57. PMid:32644218.
Bohn OL, Ruiz-Argüelles G, Navarro L, Saldivar J, Sanchez-Sosa S. Cutaneous langerhans cell sarcoma: A case report and review of the literature. Int J Hematol. 2007;85(2):116-20. PMid:17321988.
Pileri SA, Grogan TM, Harris NL, et al. Tumours of histiocytes and accessory dendritic cells: An immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology. 2002;41(1):1-29 PMid:12121233.
Shao H, Xi L, Raffeld M, et al. Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: A study of seven cases. Mod Pathol. 2011;24(11):1421-32. PMid:21666687 PMCid:PMC3175277.
Kim SW, Choi MK, Han HS, et al. A case of pulmonary langerhans cell sarcoma simultaneously diagnosed with cutaneous langerhans cell histiocytosis studied by whole-exome sequencing. Acta Haematol. 2017;138(1):24-30. PMid:28614815.
Lee JS, Gyung HK, Ho CK, In SJ, Jeon KN, Lee JH. Langerhans cell sarcoma arising from langerhans cell histiocytosis: A case report. J Korean Med Sci. 2006;21(3):577. PMid:16778410 PMCid:PMC2729972.
Ben-Ezra J, Bailey A, Azumi N, et al. Malignant histiocytosis X. A distinct clinicopathologic entity. Cancer. 1991;68(5):1050.<1050::AID-CNCR2820680524>3.0.CO;2-K PMid:1913475.
Tani M, Ishii N, Kumagai M, Ban M, Sasase A, Mishima Y. Malignant langerhans cell tumour. Br J Dermatol. 1992;126(4):398-403. PMid:1571264.
Kairouz S, Hashash J, Kabbara W, Mchayleh W, Tabbara IA. Dendritic cell neoplasms: An overview. Am J Hematol. 2007;82(10):924-8. PMid:17636477.
Nakamine H, Yamakawa M, Yoshino T, Fukumoto T, Enomoto Y, Matsumura I. Langerhans cell histiocytosis and langerhans cell sarcoma: Current understanding and differential diagnosis. J Clin Exp Hematop. 2016;56(2):109-18. PMid:27980300 PMCid:PMC6144204.
Favara BE, Jaffe R. Pathology of langerhans cell histiocytosis. Hematol Oncol Clin North Am. 1987;1(1):75. PMid:3312150.
Greenberger JS, Crocker AC, Vawter G, Jaffe N, Robert Cassady J. Results of treatment of 127 patients with systemic histiocytosis (letterer-siwe syndrome, schuller-christian syndrome and multifocal eosinophilic granuloma). Medicine (Baltimore). 1981;60(5):311-38. PMid:6974293.
Lauritzen AF, Delsol G, Hansen NE, et al. Histiocytic sarcomas and monoblastic leukemias: A clinical, histologic, and immunophenotypical study. Am J Clin Pathol. 1994;102(1):45-54. PMid:8037167.
Kawase T, Hamazaki M, Ogura M, et al. CD56/NCAM-positive langerhans cell sarcoma: A clinicopathologic study of 4 cases. Int J Hematol. 2005;81(5):323-9. PMid:15914364.
Tella SH, Kommalapati A, Rech KL, Go RS, Goyal G. Incidence, clinical features, and outcomes of langerhans cell sarcoma in the United States. Clin Lymphoma Myeloma Leuk. 2019;19(7):441-6. PMid:31005630.
Zupic I, Čater T. Bibliometric methods in management and organization. Organ Res Methods. 2015;18(3):429-72.
Al Hamad M, Lasrado S, Albarbari HS, et al. Research productivity in the genetics of papillary thyroid carcinoma (1991-2020): A bibliometric analysis. Acta Biomed. 2022; 93(3):e2022086. PMid:35775768 PMCid:PMC9335417.
Zhang B, Rahmatullah B, Wang SL, Zhang G, Wang H, Ebrahim NA. A bibliometric of publication trends in medical image segmentation: Quantitative and qualitative analysis. J Appl Clin Med Phys. 2021;22(10):45-65. PMid:34453471 PMCid:PMC8504607.
Bartoli A, Medvet E. Bibliometric evaluation of researchers in the Internet age. Inf Soc. 2014;30(5):349-54.
Hayes CJH, Coolidge HJ, Lord RH, Coolidge AC. Archibald cary coolidge, life and letters. New Engl Q. 1933;6(1):180.
Howard JEF, Masterson L, Dwivedi RC, Jani P. Langerhans cell sarcoma of the head and neck. Crit Rev Oncol Hematol. 2016;99:180-8. PMid:26777877.
Imamura M, Sakamoto S, Hanazono H. Malignant histiocytosis: A case of generalized histiocytosis with infiltration of langerhans’ granule-containing histiocytes. Cancer. 1971;28(2):467-75.<467::AID-CNCR2820280228>3.0.CO;2-9 PMid:5566366.
Mohanty P, Sahoo N, Lenka A, Bhattacharyya S. Unusual presentation of langerhans cell sarcoma as bilateral submandibular gland swelling–A rare case report. Indian J Cancer. 2022;59(1):123-7. PMid:35645054.
Nakagawa N, Yamazaki H, Yamashita T, Kondo Y, Nakao S. Successful treatment with total cranial irradiation for central nervous system involvement of langerhans cell sarcoma during chemotherapy. Rinsho Ketsueki. 2016;57(1):25-30. PMid:26861100.
Ren JJ, Zhao Y, Liu MJ, Liu G, Chen F. Langerhans cell sarcoma arising from the root of tongue: A rare case. Int J Clin Exp Pathol. 2015;8(11):15312-5. PMid:26823886 PMCid:PMC4713672.
Keklik M, Sivgin S, Kontas O, Abdulrezzak U, Kaynar L, Cetin M. Langerhans cell sarcoma of the nasopharynx: A rare case. Scott Med J. 2013;58(4):e17-20. PMid:24215052.
Yi W, Chen WY, Yang TX, Lan JP, Liang WN. Langerhans cell sarcoma arising from antecedent langerhans cell histiocytosis: A case report. Medicine (Baltimore). 2019; 98(10). PMid:30855438 PMCid:PMC6417513.
Furmanczyk PS, Lisle AE, Caldwell RB, et al. Langerhans cell sarcoma in a patient with hairy cell leukemia: Common clonal origin indicated by identical immunoglobulin gene rearrangements. J Cutan Pathol. 2012;39(6):644-50. PMid:22616604.
Chen W, Jaffe R, Zhang L, et al. Langerhans cell sarcoma arising from chronic lymphocytic lymphoma/small lymphocytic leukemia: Lineage analysis and BRAF V600E mutation study. N Am J Med Sci. 2013;5(6):386. PMid:23923114 PMCid:PMC3731871.
Tashakori M, Thakral B, Tang G, Khoury JD, Medeiros LJ. From the archives of MD Anderson Cancer Center: A case of concurrent follicular lymphoma and langerhans cell sarcoma with a review of the literature. Ann Diagn Pathol. 2021;52:151720. PMid:33676171.
Ambrosio MR, De Falco G, Rocca BJ, et al. Langerhans cell sarcoma following marginal zone lymphoma: Expanding the knowledge on mature B cell plasticity. Virchows Arch. 2015;467(4):471-80. PMid:26286813.
Ratei R, Hummel M, Anagnostopoulos I, et al. Common clonal origin of an acute B-lymphoblastic leukemia and a langerhans’ cell sarcoma: evidence for hematopoietic plasticity. Haematologica. 2010;95(9):1461. PMid:20421277 PMCid:PMC2930945.
Botin T, Navarro JT, Juncà J, Mate JL. Leukemic transformation of langerhans cell sarcoma. Med Clin (Barc). 2016;146(9):418-9. PMid:26823107.
Muslimani A, Chisti MM, Blenc AM, Boxwala I, Micale MA, Jaiyesimi I. Langerhans/dendritic cell sarcoma arising from hairy cell leukemia: A rare phenomenon. Ann Hematol. 2012;91(9):1485-7. PMid:22234838.
Fuseya H, Nakao T, Tsutsumi M, et al. Durable remission of langerhans cell sarcoma attained by autologous hematopoietic stem cell transplantation following surgical resection. Rinsho Ketsueki. 2019;60(4):314-8. PMid:31068562.
Zanelli M, Ricci S, Zizzo M, et al. Bone marrow coexistence of chronic lymphocytic leukemia and langerhans cell sarcoma. Ann Hematol. 2020;99(12):2957-9. PMid:32621179.
Papoudou-Bai A, Vassou A, Marinos L, Papathanasiou K, Kapsali E, Kanavaros P. Concurrent cutaneous localization of langerhans cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma in a patient with a history of chronic lymphocytic leukemia/small lymphocytic lymphoma. J Cutan Pathol. 2020;47(2):161-5. PMid:31441945.
Shimono J, Miyoshi H, Arakawa F, et al. Synchronous case of follicular lymphoma and langerhans cell sarcoma in the same lymph node. Pathol Int. 2018;68(11):614-7. PMid:30255584.
Mourah S, Lorillon G, Meignin V, et al. Dramatic transient improvement of metastatic BRAF(V600E)-mutated langerhans cell sarcoma under treatment with dabrafenib. Blood. 2015;126(24):2649-52. PMid:26468227.
Jouenne F, Reger De Moura C, Lorillon G, et al. RASA1 loss in a BRAF-mutated langerhans cell sarcoma: a mechanism of resistance to BRAF inhibitor. Ann Oncol. 2019;30(7):1170-2. PMid:30977771.
Go H, Jeon YK, Huh J, et al. Frequent detection of BRAF(V600E) mutations in histiocytic and dendritic cell neoplasms. Histopathology. 2014;65(2):261-72. PMid:24720374.
Zwerdling T, Won E, Shane L, Javahara R, Jaffe R. Langerhans cell sarcoma: Case report and review of world literature. J Pediatr Hematol Oncol. 2014;36(6):419-25. PMid:24942035.
Madakshira MG, Sharma N, Malhotra P, Bal A. Langerhans cell sarcoma with BRAF-V600E mutation and hemophagocytosis: An autopsy report. Indian J Cancer. 2022;59(1):119-22. PMid:35645053.
Subbiah V, Subbiah IM. Killing two birds with one stone: BRAF V600E inhibitor therapy for hairy cell leukemia and langerhans/dendritic cell sarcoma. Ann Hematol. 2013; 92(8):1149. PMid:23322213.
Karai LJ, Sanik E, Ricotti CA, Susa J, Sinkre P, Aleodor AA. Langerhans cell sarcoma with lineage infidelity/plasticity: A diagnostic challenge and insight into the pathobiology of the disease. Am J Dermatopathol. 2015;37(11):854-61. PMid:26368646.
Katsuragawa H, Yamada Y, Ishida Y, et al. A case of langerhans cell sarcoma on the scalp: Whole-exome sequencing reveals a role of ultraviolet in the pathogenesis. Pathol Int. 2020;70(11):881-7. PMid:33410565.
Choi SM, Andea AA, Wang M, et al. KRAS mutation in secondary malignant histiocytosis arising from low grade follicular lymphoma. Diagn Pathol. 2018;13(1). PMid:30322385 PMCid:PMC6190545.
Misery L, Godard W, Hamzeh H, et al. Malignant langerhans cell tumor: A case with a favorable outcome associated with the absence of blood dendritic cell proliferation. J Am Acad Dermatol. 2003;49(3):527-9. PMid:12963924.
Iwasaki K, Sakai Y, Mori M, Imamura Y. Liquid-based cytology in the diagnosis of langerhans cell sarcoma: A case report. Diagn Cytopathol. 2018;46(9):782-5. PMid:29673124.
Moustafa MA, Jiang L, Tun HW. Langerhans cell sarcoma: The Mayo Clinic experience with an extremely rare disease (Meeting Abstract). J Clin Oncol. 2020;38(15):e19543. 15_suppl.e19543.
Matsukawa T, Suto K, Miyoshi H, Oshimi K, Ohshima K, Miyagishima T. Successful treatment of an elderly langerhans cell sarcoma patient by EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) chemotherapy. J Clin Exp Hematop. 2018;58(4):184-7. PMid:30305476 PMCid:PMC6407472.
Zanwar S, Ravindran A, Abeykoon JP, et al. Prolonged remission with pembrolizumab and radiation therapy in a patient with multisystem langerhans cell sarcoma. Haematologica. 2022;107(9):2276. PMid:35615932 PMCid:PMC9425309.
Ishitsuka Y, Iwamoto K, Oya K, et al. Pegylated interferon-α2b for local control of langerhans cell sarcoma. Eur J Dermatol. 2018;28(6):835-6. PMid: 30355544.