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ORIGINAL ARTICLE
Role of HGF polymorphisms in the development of keratoconus in South Asian population
| 1 | Department of Pharmacy Practice, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin, SAUDI ARABIA |
Online publication date: 2022-12-10
Publication date: 2023-01-01
Electron J Gen Med 2023;20(1):em439
KEYWORDS
ABSTRACT
Background:
Hepatocyte growth factor (HGF) has been previously reported to be causative of keratoconus (KC) in different populations.
Aims:
The current study was conducted to investigate the role of HGF single nucleotide polymorphisms (SNPs) in sporadic KC cases from South Asian population of Pakistani origin.
Methodology:
A total of 100 sporadic cases were screened KC associated reported polymorphisms in HGF (rs17501108 and rs3735520) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
Results:
No significant association of the HGF SNPs were observed in the sporadic cases of KC and possibility of involvement of another gene in the pathogenesis of KC exist.
Conclusion:
Present study came with the findings that although globally an association exit between HGF and KC but genotyping data of Asian population of Pakistan origin does not show any association between HGF and pathogenesis of KC.
Hepatocyte growth factor (HGF) has been previously reported to be causative of keratoconus (KC) in different populations.
Aims:
The current study was conducted to investigate the role of HGF single nucleotide polymorphisms (SNPs) in sporadic KC cases from South Asian population of Pakistani origin.
Methodology:
A total of 100 sporadic cases were screened KC associated reported polymorphisms in HGF (rs17501108 and rs3735520) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
Results:
No significant association of the HGF SNPs were observed in the sporadic cases of KC and possibility of involvement of another gene in the pathogenesis of KC exist.
Conclusion:
Present study came with the findings that although globally an association exit between HGF and KC but genotyping data of Asian population of Pakistan origin does not show any association between HGF and pathogenesis of KC.
REFERENCES (22)
1.
Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42(4):297-319. https://doi.org/10.1016/S0039-... PMid:9493273.
2.
Atilano SR, Coskun P, Chwa M, et al. Accumulation of mitochondrial DNA damage in keratoconus corneas. Invest Ophthalmol Vis Sci. 2005;46(4):1256-63. https://doi.org/10.1167/iovs.0... PMid:15790887.
3.
Avetisov SE, Mamikonian VR, Novikov IA. [The role of tear acidity and Cu-cofactor of lysyl oxidase activity in the pathogenesis of keratoconus]. Vestn Oftalmol. 2011;127(2):3-8.
4.
Romero-Jimenez M, Santodomingo-Rubido J, Wolffsohn JS. Keratoconus: A review. Cont Lens Anterior Eye. 2010;33(4):157-66. https://doi.org/10.1016/j.clae... PMid:20537579.
5.
Rabinowitz YS. The genetics of keratoconus. Ophthalmol Clin North Am. 2003;16(4):607-20. https://doi.org/10.1016/S0896-... PMid:14741001.
6.
Mohd-Ali B, Liew LY, Tai HJ, Wong YY. Tears evaluation of one sample of keratoconus patients in kuala lumpur. Med J Malaysia. 2011;66(1):53-5.
7.
Hashemi H, Beiranvand A, Khabazkhoob M, et al. Prevalence of keratoconus in a population-based study in Shahroud. Cornea. 2013;32(11):1441-5. https://doi.org/10.1097/ICO.0b... PMid:24042484.
8.
Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28(4):293-322. https://doi.org/10.1016/0039-6... PMid:6230745.
9.
Lim N, Vogt U. Characteristics and functional outcomes of 130 patients with keratoconus attending a specialist contact lens clinic. Eye (Lond). 2002;16(1):54-9. https://doi.org/10.1038/sj.eye... PMid:11913889.
10.
Owens H, Gamble G. A profile of keratoconus in New Zealand. Cornea. 2003;22(2):122-5. https://doi.org/10.1097/000032... PMid:12605045.
11.
Tyynismaa H, Sistonen P, Tuupanen S, et al. A locus for autosomal dominant keratoconus: Linkage to 16q22.3-q23.1 in Finnish families. Invest Ophthalmol Vis Sci. 2002;43(10):3160-4.
12.
Wang Y, Rabinowitz YS, Rotter JI, Yang H. Genetic epidemiological study of keratoconus: Evidence for major gene determination. Am J Med Genet. 2000;93(5):403-9. https://doi.org/10.1002/1096-8...<403::AID-AJMG11>3.0.CO;2-A PMid:10951465.
13.
Tuft SJ, Hassan H, George S, Frazer DG, Willoughby CE, Liskova P. Keratoconus in 18 pairs of twins. Acta Ophthalmol. 2012;90(6):e482-6. https://doi.org/10.1111/j.1755... PMid:22682160.
14.
Nowak DM, Gajecka M. The genetics of keratoconus. Middle East Afr J Ophthalmol. 2011;18(1):2-6. https://doi.org/10.4103/0974-9... PMid:21572727 PMCid:PMC3085147.
15.
Wilson SE, He YG, Weng J, Zieske JD, Jester JV, Schultz GS. Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility, and differentiation of human corneal epithelial cells. Exp Eye Res. 1994;59(6):665-78. https://doi.org/10.1006/exer.1... PMid:7698260.
16.
Karseras AG, Ruben M. Aetiology of keratoconus. Br J Ophthalmol. 1976;60(7):522-5. https://doi.org/10.1136/bjo.60... PMid:952827 PMCid:PMC1017543.
17.
Bawazeer AM, Hodge WG, Lorimer B. Atopy and keratoconus: A multivariate analysis. Br J Ophthalmol. 2000;84(8):834-6. https://doi.org/10.1136/bjo.84... PMid:10906086 PMCid:PMC1723585.
18.
Hartstein J. Keratoconus that developed in patients wearing corneal contact lenses. Report of four cases. Arch Ophthalmol. 1968;80(3):345-6. https://doi.org/10.1001/archop... PMid:5670688.
19.
Falls HF, Allen AW. Dominantly inherited keratoconus. J Genet Hum. 1969;17(3):317-24.
20.
Georgiou T, Funnell CL, Cassels-Brown A, O’Conor R. Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients. Eye (Lond). 2004;18(4):379-83. https://doi.org/10.1038/sj.eye... PMid:15069434.
21.
Pearson AR, Soneji B, Sarvananthan N, Sandford-Smith JH. Does ethnic origin influence the incidence or severity of keratoconus? Eye (Lond). 2000;14(Pt 4):625-8. https://doi.org/10.1038/eye.20... PMid:11040911.
22.
Wojcik KA, Kaminska A, Blasiak J, Szaflik J, Szaflik JP. Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy. Int J Mol Sci. 2013;14(9):19294-308. https://doi.org/10.3390/ijms14... PMid:24065107 PMCid:PMC3794834.
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