The Chromophobe Renal Cell Carcinoma with Sarcomatoid Differentiation
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Department of Urology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey
Department of Pathology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, 46050 Kahramanmaras, Turkey
Can Benlioglu, M.D. Department of Urology, 7 Mart Hospital, Kadirli, Turkey
Publication date: 2014-01-08
Corresponding author
Sefa Resim   

Kahramanmaras Sutcu Imam University Medical Faculty, Department of Urology, 46050, Kahramanmaras-Turkey
Eur J Gen Med 2014;11(Supplement 1):14-17
We present a rare case of a 52-year-old woman with a chromofobe renal cell carcinoma that had sarcomatoid components. The tumor, 70x60mm in size, was incidentally found by abdominal ultrasonography. An abdominal computed tomography demonstrated a well-demarcated solid tumor arising from the upper pole of the right kidney. Histologically, the tumor was composed of two intermixed distinct morphologic components: a chromophobe renal cell carcinoma and a high-grade spindle cell sarcoma. There was a sarcomatoid area composed of highly atypical spindle cells intermingled with rhabdoid cells. A unique histological finding of this tumor was the presence of calcification and psammoma body formation throughout the tumor. We think that this case supports the existence of a tumor progression pathway from chromofob to sarcomatoid renal cell carcinoma. A literature review on sarcomatoid chromofobe renal cell carcinoma with calcification was performed
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