Comparative studies of influence of palm oil on activity of xanthine oxidase and free radicals in liver and blood: Diabetes and metabolic syndrom
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Alma Mater Europaea Campus College “Rezonanca”, Pristina, KOSOVO
Online publication date: 2023-11-09
Publication date: 2023-11-09
Electron J Gen Med 2023;20(6):em551
Diabetes is a chronic metabolic disease, which has affected approximately 10.5% of the global population [1]. The most frequent types of diabetes are type-1 and type-2. The third frequent type is gestational diabetes. The pathogenicity of diabetes is multifactorial and involves various factors such as genetic, food, stress, environmental pollutants, and others, in most of the cases combination of two or more factors are noticed. Comparative studies of the influence of palm oil on the activity of xanthine oxidase (XOD) and free radicals in liver and blood. The research compared the effect of palm oil on carbohydrate metabolism in male rats: in young rats and adult rats. The research compared the effect of palm oil on free radicals in male rats: in adults and juvenile rats. Experimental animal body weight change research, 30 days after palm oil treatment. For this scientific research we utilized experimental animals of the male genus: mice of the Wistar type, small mice (45-60 g) and large mice (160-180 g). Experimental animals were divided into groups of six-eight experimental mice and details are shown in the corresponding part of the results. The results are shown in six figures and two tables. Results indicate an increase in the formation of free radicals in blood plasma, both in experimental juvenile mice and in experimental large mice under the influence of palm oil. Palm oil increases the activity of XOD in blood, both in small animals and in large experimental animals. Palm oil increases the formation of XOD in the black liver in both elderly groups. In all groups during the experiment there was an increase in body weight. Results from studies of the effect of palm oil on carbohydrate metabolism showed changes in glucose tolerance test. Current studies for the first time convincingly demonstrate the risk of using palm oil. Analysis of the results of two studies on XOD and carbohydrate metabolism showed a correlation between increased XOD levels and the development of prediabetes.
Sun H, Saeedi P, Karuranga S, et al. IDF diabetes atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. PMid:34879977.
Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539-53.<539::AID-DIA668>3.0.CO;2-S.
Balkau B, Charles MA. Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabet Med. 1999;16(5):442-3. PMid:10342346.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001;285(19):2486-97. PMid:11368702.
Einhorn D, Reaven GM, Cobin RH, et al. American College of Endocrinology position statement on the insulin resistance syndrome. Endocr Pract. 2003;9(3):237-52. PMid:12924350.
Alberti KG, Zimmet P, Shaw J. The metabolic syndrome–A new worldwide definition. Lancet. 2005;366(9491):1059-62. PMid:16182882.
Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640-5. PMid:19805654.
Erlich DR, Slawson DC, Shaughnessy A. Diabetes update: Screening and diagnosis. FP Essent. 2013;408:11-3.
Bedard K, Krause K-H. The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology. Physiol Rev. 2007;87(1):245-313. PMid:17237347.
Sautin YY, Johnson RJ. Uric acid: The oxidant-antioxidant paradox. Nucleosites Nucleotides Nucleic Acids. 2008; 27(6):608-19. PMid:18600514 PMCid:PMC2895915.
Memedi B, Traykova M, Boyadjieva N. Effect of palm oil and animal fat on the free radicals in the blood plasma and liver of juvenile rat exposed to a fat-rich diet. Trakia J Sci. 2012;10(1):321-5.
Furukawa S, Fujita T, Shimabukuro M, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114(12):1752-61. PMid:15599400 PMCid:PMC535065.
Mancini A, Imperlini E, Nigro E, et al. Biological and nutritional properties of palm oil and palmitic acid: Effects on health. Molecules. 2015;20(9):17339-61. PMid:26393565 PMCid:PMC6331788.
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