Impact of supplemental vitamin D3 and calcium on hypercholesterolemia
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School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Internal Medicine, AJA University of Medical Sciences, Tehran, Iran
Department of Social Medicine, School of Medicine, AJA University of Medical Sciences, Tehran, Iran
Submission date: 2018-02-02
Final revision date: 2018-02-21
Acceptance date: 2018-02-23
Online publication date: 2018-03-03
Publication date: 2018-03-03
Electron J Gen Med 2018;15(3):em27
In the present crossover study, we aimed to assess if calcium and vitamin D can help statins for treatment of hypercholesterolemia.

This crossover study was conducted on 60 participants with newly diagnosed hypercholesterolemia. In first phase of study, all patients were administered one 20-mg tablet of atorvastatin every bedtime for sex weeks. Thereafter, in the second phase, all participants received 400 IU vitamin D3 and 1000 mg calcium in addition to previous regimen. After each phase, Lipid profile was evaluated for all participants.

60 individuals including 26 men (43.3%) and 34 women (56.7%) participated in this study. There was significant decrease in triglyceride, total cholesterol and LDL after six weeks treatment with atorvastatin. However, HDL showed no significant change. When blood lipid values after statin therapy was compared to the values after treatment with atorvastatin plus supplemental calcium and vitamin D3, none showed statistically significant change. BMI was found to decrease significantly in both phase of treatment, but blood pressure showed no change.

In summary, we observed that supplemental calcium and vitamin D3 have no significant impact on lipid profile and blood pressure. However, we found that supplemental calcium and vitamin D3 decreased BMI, but more studies are in need to support our results.

Zipes D, Libby P, Bonow R. Braunwald e. Braunwald’s heart disease. Philadelphia: Elsevier Saunders; 2005. PMCid:PMC1193893.
Goff DC, Jr., Bertoni AG, Kramer H, Bonds D, Blumenthal RS, Tsai MY, et al. Dyslipidemia prevalence, treatment, and control in the Multi-Ethnic Study of Atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium. Circulation. 2006;113(5):647-56. https://doi.org/10.1161/CIRCUL... PMid:16461837.
Nguyen NT, Magno CP, Lane KT, Hinojosa MW, Lane JS. Association of hypertension, diabetes, dyslipidemia, and metabolic syndrome with obesity: findings from the National Health and Nutrition Examination Survey, 1999 to 2004. Journal of the American College of Surgeons. 2008;207(6):928-34. https://doi.org/10.1016/j.jamc... PMid:19183541.
Furuncuoglu Y, Basar M, Alıcı S, Sengul C. Effects of a Stanol-Enriched Yogurt on Plasma Cholesterol Levels. European Journal of General Medicine. 2014;11(4):230-4. https://doi.org/10.15197/sabad....
Noori N, Mirmiran P, Asgari S, Azizi F. Dietary intake of calcium and vitamin D and the prevalence of metabolic syndrome in Tehranian adults: Tehran Lipid and Glucose Study (TLGS). Iranian Journal of Endocrinology and Metabolism. 2007;9(2):191-200.
Zemel MB, Thompson W, Milstead A, Morris K, Campbell P. Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obesity research. 2004;12(4):582-90. https://doi.org/10.1038/oby.20... PMid:15090625.
Zemel MB. Regulation of adiposity and obesity risk by dietary calcium: mechanisms and implications. J Am Coll Nutr. 2002;21(2):146s-51s. https://doi.org/10.1080/073157... PMid:11999543.
Reid IR, Horne A, Mason B, Ames R, Bava U, Gamble GD. Effects of calcium supplementation on body weight and blood pressure in normal older women: a randomized controlled trial. The Journal of clinical endocrinology and metabolism. 2005;90(7):3824-9. https://doi.org/10.1210/jc.200... PMid:15827103.
Shapses SA, Heshka S, Heymsfield SB. Effect of calcium supplementation on weight and fat loss in women. The Journal of clinical endocrinology and metabolism. 2004;89(2):632-7. https://doi.org/10.1210/jc.200... PMid:14764774 PMCid:PMC4010554.
Saedisomeolia A, Taheri E, Djalali M, Moghadam AM, Qorbani M. Association between serum level of vitamin D and lipid profiles in type 2 diabetic patients in Iran. Journal of diabetes and metabolic disorders. 2014;13(1):7. https://doi.org/10.1186/2251-6... PMid:24398023 PMCid:PMC3937161.
Tehrani HG, Mostajeran F, Shahsavari S. The effect of calcium and vitamin D supplementation on menstrual cycle, body mass index and hyperandrogenism state of women with poly cystic ovarian syndrome. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. 2014;19(9):875-80.
Mehta V. Emergence of new risk factors for causing hypertension. Journal of Medical Research and Innovation. 2017;1(1):9-11. https://doi.org/10.15419/jmri.....
Margolis KL, Ray RM, Van Horn L, Manson JE, Allison MA, Black HR, et al. Effect of calcium and vitamin D supplementation on blood pressure: the Women’s Health Initiative Randomized Trial. Hypertension (Dallas, Tex: 1979). 2008;52(5):847-55. https://doi.org/10.1161/HYPERT... PMid:18824662 PMCid:PMC2791957.
Goel RK, Lal H. Role of vitamin d supplementation in hypertension. Indian journal of clinical biochemistry: IJCB. 2011;26(1):88-90. https://doi.org/10.1007/s12291... PMid:22211023 PMCid:PMC3068764.
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