Multi-segment bioimpedance in the evaluation of treatment for secondary lower limb lymphedema: Gynecological cancer
More details
Hide details
Medicine School in São José do Rio Preto, São José do Rio Preto, BRAZIL
Clínica Godoy, São Jose do Rio Preto, BRAZIL
National Council for Scientific and Technological Development, Lago Sul, BRAZIL
Online publication date: 2023-04-03
Publication date: 2023-07-01
Electron J Gen Med 2023;20(4):em491
The present aimed study was to report the mobilization of body fluids after five days of intensive treatment for secondary lower limb lymphedema.

Materials and methods:
A crossover clinical trial was conducted involving the analysis of changes in intracellular and extracellular fluids in all extremities and the trunk in women with lower limb lymphedema secondary to treatment for gynecological cancer. Evaluations were performed with multi-segment bio impedance analysis before and after intensive treatment using Godoy Method® eight hours per day for five days. Comparisons were made using Wilcoxon signed-ranks test.

Significant changes in intracellular and extracellular fluids were found in all extremities and the trunk (p<0.0001 for all comparisons).

Intensive Godoy Method® leads to important changes in the distribution of body fluids in the treatment of lower limb lymphedema following treatment for gynecological cancer, with a significant increase in fluids in the upper limbs and trunk as well as significant reductions in the lower limb and in intracellular and extracellular water.

Kuroda K, Yamamoto Y, Yanagisawa M, et al. Risk factors and a prediction model for lower limb lymphedema following lymphadenectomy in gynecologic cancer: A hospital-based retrospective cohort study. BMC Womens Health. 2017;17(1):50. https://doi.org/10.1186/s12905... PMid:28743274 PMCid:PMC5526302.
Pereira de Godoy JM, Guerreiro Godoy MdF. Evaluation of a new approach to the treatment of lymphedema resulting from breast cancer therapy. Eur J Intern Med. 2013;24(1):59-62. https://doi.org/10.1016/j.ejim... PMid:22964259.
Chaput G, Ibrahim M, Towers A. Cancer-related lymphedema: Clinical pearls for providers. Curr Oncol. 2020;27(6):336-0. https://doi.org/10.3747/co.27.... PMid:33380866 PMCid:PMC7755442.
Shallwani SM, Towers A, Newman A, et al. Feasibility of a pilot randomized controlled trial examining a multidimensional intervention in women with gynecological cancer at risk of lymphedema. Curr Oncol. 2021;28(1):455-70. https://doi.org/10.3390/curron... PMid:33450972 PMCid:PMC7903266.
Glaser G, Dinoi G, Multinu F, et al. Reduced lymphedema after sentinel lymph node biopsy versus lymphadenectomy for endometrial cancer. Int J Gynecol Cancer. 2021;31(1):85-91. https://doi.org/10.1136/ijgc-2... PMid:33243776.
Rebegea LF, Stoleriu G, Manolache N, et al. Associated risk factors of lower limb lymphedema after treatment of cervical and endometrial cancer. Exp Ther Med. 2020;20(6):181. https://doi.org/10.3892/etm.20... PMid:33101471 PMCid:PMC7579779.
Kendrová L, Mikuľáková W, Urbanová K, et al. Comprehensive decongestive therapy as a treatment for secondary lymphedema of the lower extremity and quality of life of women after gynecological cancer surgery. Med Sci Monit. 2020;26:e924071. https://doi.org/10.12659/MSM.9... PMid:32555125 PMCid:PMC7320633.
Wu X, Liu Y, Zhu D, Wang F, Ji J, Yan H. Early prevention of complex decongestive therapy and rehabilitation exercise for prevention of lower extremity lymphedema after operation of gynecologic cancer. Asian J Surg. 2021;44(1):111-115. https://doi.org/10.1016/j.asjs... PMid:32402630.
Wang X, Ding Y, Cai HY, et al. Effectiveness of modified complex decongestive physiotherapy for preventing lower extremity lymphedema after radical surgery for cervical cancer: A randomized controlled trial. Int J Gynecol Cancer. 2020;30(6):757-63. https://doi.org/10.1136/ijgc-2... PMid:32107315.
Pereira de Godoy JM, Guerreiro Godoy MdF, Barufi S, Pereira de Godoy HJ. Intensive treatment of lower-limb lymphedema and variations in volume before and after: A follow-up. Cureus. 2020;12(10):e10756. https://doi.org/10.7759/cureus....
Pereira de Godoy JM, Pereira de Godoy HJ, Pereira de Godoy AC, Graciano de Marqui T, Guerreiro Godoy MdF. Lymphedema and the mobilization of intracellular and extracellular fluids with intensive treatment. Acta Phlebol. 2019;20:57-60. https://doi.org/10.23736/S1593....
Pereira de Godoy JM, Pereira de Godoy LM, Guerreiro Godoy MdF. Prevalence of subclinical systemic lymphedema in patients following treatment for breast cancer and association with body mass index. Cureus. 2020;12(3):e7291. https://doi.org/10.7759/cureus....
Guerreiro Godoy MdF, Barufi S, Pereira de Godoy Capeletto P, Pereira de Godoy HJ, Pereira de Godoy JM. Grosgrain stockings in the treatment of primary congenital lymphedema. Electron J Gen Med. 2021;18(1):em354. https://doi.org/10.29333/ejgm/....
Asklöf M, Kjølhede P, Wodlin NB, Nilsson L. Bioelectrical impedance analysis; a new method to evaluate lymphoedema, fluid status, and tissue damage after gynaecological surgery–A systematic review. Eur J Obstet Gynecol Reprod Biol. 2018;228:111-9. https://doi.org/10.1016/j.ejog... PMid:29933195.
Forte AJ, Huayllani MT, Boczar D, et al. Use of bioimpedance spectroscopy for prospective surveillance and early diagnosis of breast cancer-related lymphedema. Breast Dis. 2021;40(2):85-93. https://doi.org/10.3233/BD-201... PMid:33646139.
Pereira de Godoy JM, Pereira de Godoy LM, Guerreiro Godoy MdF, Neto DS. Physiological stimulation of the synthesis of preelastic fibers in the dermis of a patient with fibrosis. Case Rep Med. 2021;2021:2666867. https://doi.org/10.1155/2021/2... PMid:35003267 PMCid:PMC8739906.
Pereira de Godoy JM, Guerreiro Godoy MdF, Pereira de Godoy HJ, De Santi Neto D. Stimulation of synthesis and lysis of extracellular matrix proteins in fibrosis associated with lymphedema. Dermatopathology (Basel). 2022;9(1):1-10. https://doi.org/10.3390/dermat... PMid:35076482 PMCid:PMC8788559.
Journals System - logo
Scroll to top