Obesity indices as risk factor for colorectal cancer in patients at a national police hospital in Peru
More details
Hide details
Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, PERU
Online publication date: 2023-04-03
Publication date: 2023-07-01
Electron J Gen Med 2023;20(4):em492
Colorectal cancer (CRC) represents the third most diagnosed form of cancer around the world, accounting for 11% of all cancer diagnoses. It has been seen that obesity is closely linked to this disease.

Materials and Methods:
This study is a non-paired case-control study. To measure obesity, the body mass index (BMI), new body mass index (NBMI), and the triponderal index (TPI) were used. Logistic regression was used to obtain the adjusted odds ratio (aOR) by age and sex, confidence interval (95%CI).

The sample was 246 patients. The prevalence of obesity according to BMI was 12.20%. The multivariable analysis found statistically significant association between CRC and obesity according to BMI (aOR: 3.23; 95% CI 1.26-8.30) compared to normal weight; NBMI tertile 3 (aOR: 4.02; 95% CI 1.95-8.30), compared to tertile 1; and TPI tertile 3 (aOR: 4.55; 95% CI 2.21-9.35) versus tertile 1

Obesity, is a risk factor for CRC. Future studies might consider useful different ways to measure obesity to define population strata with a higher-risk of CRC.

Goss PE, Lee BL, Badovinac-Crnjevic T, et al. Planning cancer control in Latin America and the Caribbean. Lancet Oncol. 2013;14(5):391-436. https://doi.org/10.1016/s1470-... PMid:23628188.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. https://doi.org/10.3322/caac.2... PMid:30207593.
Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: Incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019;14(2):89-103. https://doi.org/10.5114/pg.201... PMid:31616522 PMCid:PMC6791134.
La obesidad y el cancer [Obesity and cancer]. CDC; 2021. Available at: https://www.cdc.gov/spanish/ca... (Accessed: 29 May 2022).
Robsahm TE, Aagnes B, Hjartåker A, Langseth H, Bray FI, Larsen IK. Body mass index, physical activity, and colorectal cancer by anatomical subsites: A systematic review and meta-analysis of cohort studies. Eur J Cancer Prev. 2013;22(6):492-505. https://doi.org/10.1097/cej.0b... PMid:23591454.
Low EE, Demb J, Liu L, et al. Risk factors for early-onset colorectal cancer. Gastroenterol. 2020;159(2):492-501.E7. https://doi.org/10.1053/j.gast... PMid:31926997 PMCid:PMC7343609.
Yeste D, Clemente M, Campos A, et al. Precisión diagnóstica del índice de masa triponderal (kg/m3) para identificar el fenotipo de riesgo metabólico en pacientes obesos [Diagnostic accuracy of the triponderal mass index (kg/m3) to identify the metabolic risk phenotype in obese patients]. Ann Pediatr. 2021;94(2):68-74. https://doi.org/10.1016/j.anpe... PMid:32446672.
New BMI (new body mass index). Body mass index. Available at: https://people.maths.ox.ac.uk/... (Accessed: 29 May 2022).
Ulaganathan V, Kandiah M, Shariff ZM. A case-control study on the association of abdominal obesity and hypercholesterolemia with the risk of colorectal cancer. J Carcinog. 2018;17:4. https://doi.org/10.4103/jcar.j... PMid:30294246 PMCid:PMC6166417.
Burton RF. Why is the body mass index calculated as mass/height2, not as mass/height3? Ann Hum Biol. 2007;34(6):656-63. https://doi.org/10.1080/030144... PMid:18092209.
van Vugt JLA, Cakir H, Kornmann VNN, et al. The new body mass index as a predictor of postoperative complications in elective colorectal cancer surgery. Clin Nutr. 2015;34(4):700-4. https://doi.org/10.1016/j.clnu... PMid:25171837.
Arnold M, Touillaud M, Dossus L, et al. Cancers in France in 2015 attributable to high body mass index. Cancer Epidemiol. 2018;52:15-9. https://doi.org/10.1016/j.cane... PMid:29161609.
García H, Marina O, Wood Rodríguez L, Galbán García E, Vázquez A, del Rosario M. Factores de riesgo para el cáncer colorrectal [Factores de riesgo para el cáncer colorrectal]. Cuban J Med. 2011;50(2):118-32.
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE. Association of colonoscopy adenoma findings with long-term colorectal cancer incidence. JAMA. 2018;319(19):2021-31. https://doi.org/10.1001/jama.2... PMid:29800214 PMCid:PMC6583246.
Nguyen LH, Goel A, Chung DC. Pathways of colorectal carcinogenesis. Gastroenterology. 2020;158(2):291-302. https://doi.org/10.1053/j.gast... PMid:31622622 PMCid:PMC6981255.
He X, Hang D, Wu K, et al. Long-term risk of colorectal cancer after removal of conventional adenomas and serrated polyps. Gastroenterology. 2020;158(4):852-61.e4. https://doi.org/10.1053/j.gast... PMid:31302144 PMCid:PMC6954345.
Siegel RL, Jakubowski CD, Fedewa SA, Davis A, Azad NS. Colorectal cancer in the young: Epidemiology, prevention, management. Am Soc Clin Oncol Educ Book. 2020;(40):e75-88. https://doi.org/10.1200/edbk_2... PMid:32315236.
Levi Z, Kark JD, Katz LH, et al. Adolescent body mass index and risk of colon and rectal cancer in a cohort of 1.79 million Israeli men and women: A population-based study. Cancer. 2017;123(20):4022-30. https://doi.org/10.1002/cncr.3... PMid:28736986.
Brenner DR, Ruan Y, Shaw E, De P, Heitman SJ, Hilsden RJ. Increasing colorectal cancer incidence trends among younger adults in Canada. Prev Med. 2017;105:345-9. https://doi.org/10.1016/j.ypme... PMid:28987338.
Jensen BW, Gamborg M, Gögenur I, Renehan AG, Sørensen TIA, Baker JL. Childhood body mass index and height in relation to site-specific risks of colorectal cancers in adult life. Eur J Epidemiol. 2017;32(12):1097-106. https://doi.org/10.1007/s10654... PMid:28803329.
Hanyuda A, Cao Y, Hamada T, et al. Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status. Eur J Epidemiol. 2017;32(5):393-407. https://doi.org/10.1007/s10654... PMid:28510098 PMCid:PMC5507723.
Shaukat A, Dostal A, Menk J, Church TR. BMI is a risk factor for colorectal cancer mortality. Dig Dis Sci. 2017;62(9):2511-7. https://doi.org/10.1007/s10620... PMid:28733869.
Dong Y, Zhou J, Zhu Y, et al. Abdominal obesity and colorectal cancer risk: Systematic review and meta-analysis of prospective studies. Biosci Rep. 2017;37(6):BSR20170945. https://doi.org/10.1042/bsr201... PMid:29026008 PMCid:PMC5725611.
Brenner H, Chen C. The colorectal cancer epidemic: Challenges and opportunities for primary, secondary and tertiary prevention. Br J Cancer. 2018;119(7):785-92. https://doi.org/10.1038/s41416... PMid:30287914 PMCid:PMC6189126.
Gathirua-Mwangi WG, Monahan P, Song Y, et al. Changes in adult BMI and waist circumference are associated with increased risk of advanced colorectal neoplasia. Dig Dis Sci. 2017;62(11):3177-85. https://doi.org/10.1007/s10620... PMid:28983748 PMCid:PMC5653429.
Grivennikov SI, Karin M. Inflammatory cytokines in cancer: Tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis. 2011;70 Suppl 1:i104-108. https://doi.org/10.1136/ard.20... PMid:21339211.
Rezaei-Tavirani M, Safaei A, Zali MR. The association between polymorphismsin insulin and obesity related genesand risk of colorectal cancer. Iran J Cancer Prev. 2013;6(4):179-85.
Silvia Riondino, Mario Roselli, Raffaele Palmirotta, David Della-Morte, Patrizia Ferroni, Fiorella Guadagni. Obesity and colorectal cancer: Role of adipokines in tumor initiation and progression. World J Gastroenterol. 2014;20(18):5177-90. https://doi.org/10.3748/wjg.v2... PMid:24833848 PMCid:PMC4017033.
Suzuki H, Ogawa H, Miura K, et al. IL-23 directly enhances the proliferative and invasive activities of colorectal carcinoma. Oncol Lett. 2012;4(2):199-204. https://doi.org/10.3892/ol.201... PMid:22844353 PMCid:PMC3402724.
Shiga K, Hara M, Nagasaki T, et al. Preoperative serum interleukin-6 is a potential prognostic factor for colorectal cancer, including stage II patients. Gastroenterol Res Pract. 2016;2016:9701574. https://doi.org/10.1155/2016/9... PMid:26858756 PMCid:PMC4706938.
Kasprzak A, Adamek A. Insulin-like growth factor 2 (IGF2) signaling in colorectal cancer-from basic research to potential clinical applications. Int J Mol Sci. 2019;20(19):E4915. https://doi.org/10.3390/ijms20... PMid:31623387 PMCid:PMC6801528.
Zhang B, Hong C-Q, Luo Y-H, et al. Prognostic value of IGFBP2 in various cancers: A systematic review and meta-analysis. Cancer Med. 2022;11(16):3035-47. https://doi.org/10.1002/cam4.4... PMid:35546443 PMCid:PMC9385590.
Journals System - logo
Scroll to top