Could Preventing Thromboembolism be a New Hope for COVID-19 Patients?
More details
Hide details
Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRAZIL
Modestum Ltd, UK
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova - Campus of Savona, Savona, ITALY
Online publication date: 2020-05-07
Publication date: 2020-05-07
Electron J Gen Med 2020;17(6):em250
Several researches have been conducted in order to study treatment effects for COVID-19. Nevertheless, some of the current treatments have not been effective or recommended for severe cases. In this perspective article, we briefly discuss the latest developments in the COVID-19 management.
World Health Organization. Coronavirus disease 2019 (COVID-19). Situation report – 70 [Internet]. Genebra: World Health Organization; 2020. Available at: (Accessed: 26 April 2020).
Santacroce L, Charitos IA, Del Prete R. COVID-19 in Italy: an overview from the first case to date. Electron J Gen Med. 2020;17(6):em235.
Minh Duc N, Duc Ha H, Anh Tuan T, Lien Bang MT, Hong Duc P, Minh Thong P. From first COVID-19 case to current outbreak: a vietnamese report. Electron J Gen Med. 2020;17(4):em208.
Li LQ, Huang T, Wang YQ, et al. COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol. 2020. [Epub ahead of print]. PMid:32162702.
Deng Y, Liu W, Liu K, et al. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study. Chin Med J (Engl). 2020. PMid:32209890.
Johns Hopkins Coronavirus Resource Center. World Map [Internet]. Baltimore. Available at: (Accessed: 26 April 2020).
Remuzzi A, Remuzzi G. COVID-19 and Italy: what next?. Lancet. 2020;395(10231):1225-8.
Yezli S, Khan A. COVID-19 social distancing in the Kingdom of Saudi Arabia: bold measures in the face of political, economic, social and religious challenges. Travel Med Infect Dis. 2020:101692. PMid:32330561 PMCid:PMC7172679.
Abd El-Aziz TM, Stockand JD. Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status. Infect Genet Evol. 2020;83:104327. PMid:32320825 PMCid:PMC7166307.
Borba MGS, Val FFA, Sampaio VS, et al. Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial. JAMA Netw Open. 2020;3(4.23):e208857.
Spiezia L, Boscolo A, Poletto F, et al. COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure. Thromb Haemost. 2020.
Bikdeli B, Madhavan MV, Jimenez D, et al. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up. J Am Coll Cardiol. 2020. pii: S0735-1097(20)35008-7.
Zhai Z, Li C, Chen Y, et al. Prevention and treatment of venous thromboembolism associated with coronavirus disease 2019 infection: a consensus statement before guidelines.Thromb Haemost. 2020.
Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020. PMid:32220112.
Casini A, Alberio L, Angelillo-Scherrer A, et al. Thromboprophylaxis and laboratory monitoring for in-hospital patients with COVID-19 - a Swiss consensus statement by the Working Party Hemostasis. Swiss Med Wkly. 2020;150:w20247.
Valerio L, de Balanzó X, Jiménez O, Pedro-Botet ML. Haemorrhagic exanthema due to dengue virus induced by acetylsalicylic acid. An Sist Sanit Navar. 2006;29(3):439-42.
Hillegass E, Puthoff M, Frese EM, Thigpen M, Sobush DC, Auten B. Role of physical therapists in the management of individuals at risk for or diagnosed with venous thromboembolism: evidence-based clinical practice guideline. Phys Ther. 2016;96(2):143-66. PMid:26515263.
Okumuş G, Özçelik B, Sasani H, et al. Do appropriate thromboprophylaxis and routine physiotherapy prevent venous thromboembolism in intensive care unit?. Turk Gogus Kalp Dama. 2015;23(1):92-7.
Lazzeri M, Lanza A, Bellini R, et al. Respiratory physiotherapy in patients with COVID-19 infection in acute setting: a position paper of the Italian Association of Respiratory Physiotherapists (ARIR). Monaldi Arch Chest Dis. 2020;90(1):1285. PMid:32236089.
Ceravolo MG, De Sire A, Andrenelli E, Negrini F, Negrini S. Systematic rapid “living” review on rehabilitation needs due to COVID-19: update to march 31st 2020. Eur J Phys Rehabil Med. 2020. PMid:32316718.
Thomas P, Baldwin C, Bissett B, et al. Physiotherapy management for COVID-19 in the acute hospital setting: clinical practice recommendations. J Physiother. 2020. PMid:32312646 PMCid:PMC7165238.
World Health Organization. Coronavirus disease 2019 (COVID-19). Situation report – 72 [Internet]. Genebra: World Health Organization; 2020. Available at: (Accessed: 26 April 2020).